PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Markus Flosbach; Susanne G. Oberle; Stefanie Scherer; Jana Zecha; Madlaina von Hoesslin; Florian Wiede; Vijaykumar Chennupati; Jolie G. Cullen; Markus List; Josch K. Pauling; Jan Baumbach; Bernhard Kuster; Tony Tiganis; Dietmar Zehn

doi:10.1016/j.celrep.2020.107957

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Markus Flosbach
, Susanne G. Oberle
, Stefanie Scherer
, Jana Zecha
, Madlaina von Hoesslin
, Florian Wiede
, Vijaykumar Chennupati
, Jolie G. Cullen
, Markus List
, Josch K. Pauling
, Jan Baumbach
, Bernhard Kuster
, Tony Tiganis
, Dietmar Zehn

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Manipulating PTPN2 has potential for advancing immunotherapies. However, it is unclear how PTPN2 impacts the activation, survival, and memory formation of T cells. Flosbach et al. demonstrate that PTPN2-deficient T cells are less dependent on cytokines and show increased programmed expansion, and short-lived effector T cells have enhanced survival and expansion capacity.

Original language	English
Article number	107957
Journal	Cell Reports
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2020.107957
State	Published - 28 Jul 2020

Keywords

GWAS
Protein tyrosine phosphatase non‑receptor type 2 (PTPN2)
T cell memory
adoptive T cell transfer
autoimmunity
effector T cells
immunotherapy
phosphoproteome
programmed T cell expansion
single point mutation

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10.1016/j.celrep.2020.107957

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Flosbach, M., Oberle, S. G., Scherer, S., Zecha, J., von Hoesslin, M., Wiede, F., Chennupati, V., Cullen, J. G., List, M., Pauling, J. K., Baumbach, J., Kuster, B., Tiganis, T., & Zehn, D. (2020). PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells. Cell Reports, 32(4), Article 107957. https://doi.org/10.1016/j.celrep.2020.107957

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title = "PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells",

abstract = "Manipulating PTPN2 has potential for advancing immunotherapies. However, it is unclear how PTPN2 impacts the activation, survival, and memory formation of T cells. Flosbach et al. demonstrate that PTPN2-deficient T cells are less dependent on cytokines and show increased programmed expansion, and short-lived effector T cells have enhanced survival and expansion capacity.",

keywords = "GWAS, Protein tyrosine phosphatase non‑receptor type 2 (PTPN2), T cell memory, adoptive T cell transfer, autoimmunity, effector T cells, immunotherapy, phosphoproteome, programmed T cell expansion, single point mutation",

author = "Markus Flosbach and Oberle, \{Susanne G.\} and Stefanie Scherer and Jana Zecha and \{von Hoesslin\}, Madlaina and Florian Wiede and Vijaykumar Chennupati and Cullen, \{Jolie G.\} and Markus List and Pauling, \{Josch K.\} and Jan Baumbach and Bernhard Kuster and Tony Tiganis and Dietmar Zehn",

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year = "2020",

month = jul,

day = "28",

doi = "10.1016/j.celrep.2020.107957",

language = "English",

volume = "32",

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AU - Flosbach, Markus

AU - Oberle, Susanne G.

AU - Scherer, Stefanie

AU - Zecha, Jana

AU - von Hoesslin, Madlaina

AU - Wiede, Florian

AU - Chennupati, Vijaykumar

AU - Cullen, Jolie G.

AU - List, Markus

AU - Pauling, Josch K.

AU - Baumbach, Jan

AU - Kuster, Bernhard

AU - Tiganis, Tony

AU - Zehn, Dietmar

PY - 2020/7/28

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N2 - Manipulating PTPN2 has potential for advancing immunotherapies. However, it is unclear how PTPN2 impacts the activation, survival, and memory formation of T cells. Flosbach et al. demonstrate that PTPN2-deficient T cells are less dependent on cytokines and show increased programmed expansion, and short-lived effector T cells have enhanced survival and expansion capacity.

AB - Manipulating PTPN2 has potential for advancing immunotherapies. However, it is unclear how PTPN2 impacts the activation, survival, and memory formation of T cells. Flosbach et al. demonstrate that PTPN2-deficient T cells are less dependent on cytokines and show increased programmed expansion, and short-lived effector T cells have enhanced survival and expansion capacity.

KW - GWAS

KW - Protein tyrosine phosphatase non‑receptor type 2 (PTPN2)

KW - T cell memory

KW - adoptive T cell transfer

KW - autoimmunity

KW - effector T cells

KW - immunotherapy

KW - phosphoproteome

KW - programmed T cell expansion

KW - single point mutation

UR - https://www.scopus.com/pages/publications/85088627033

U2 - 10.1016/j.celrep.2020.107957

DO - 10.1016/j.celrep.2020.107957

M3 - Article

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AN - SCOPUS:85088627033

SN - 2639-1856

VL - 32

JO - Cell Reports

JF - Cell Reports

IS - 4

M1 - 107957

ER -

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Abstract

Keywords

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