PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Markus Flosbach; Susanne G. Oberle; Stefanie Scherer; Jana Zecha; Madlaina von Hoesslin; Florian Wiede; Vijaykumar Chennupati; Jolie G. Cullen; Markus List; Josch K. Pauling; Jan Baumbach; Bernhard Kuster; Tony Tiganis; Dietmar Zehn

doi:10.1016/j.celrep.2020.107957

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Markus Flosbach, Susanne G. Oberle, Stefanie Scherer, Jana Zecha, Madlaina von Hoesslin, Florian Wiede, Vijaykumar Chennupati, Jolie G. Cullen, Markus List, Josch K. Pauling, Jan Baumbach, Bernhard Kuster, Tony Tiganis, Dietmar Zehn

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Manipulating PTPN2 has potential for advancing immunotherapies. However, it is unclear how PTPN2 impacts the activation, survival, and memory formation of T cells. Flosbach et al. demonstrate that PTPN2-deficient T cells are less dependent on cytokines and show increased programmed expansion, and short-lived effector T cells have enhanced survival and expansion capacity.

Original language	English
Article number	107957
Journal	Cell Reports
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2020.107957
State	Published - 28 Jul 2020

Keywords

GWAS
Protein tyrosine phosphatase non‑receptor type 2 (PTPN2)
T cell memory
adoptive T cell transfer
autoimmunity
effector T cells
immunotherapy
phosphoproteome
programmed T cell expansion
single point mutation

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10.1016/j.celrep.2020.107957

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Flosbach, M., Oberle, S. G., Scherer, S., Zecha, J., von Hoesslin, M., Wiede, F., Chennupati, V., Cullen, J. G., List, M., Pauling, J. K., Baumbach, J., Kuster, B., Tiganis, T., & Zehn, D. (2020). PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells. Cell Reports, 32(4), Article 107957. https://doi.org/10.1016/j.celrep.2020.107957

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title = "PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells",

abstract = "Manipulating PTPN2 has potential for advancing immunotherapies. However, it is unclear how PTPN2 impacts the activation, survival, and memory formation of T cells. Flosbach et al. demonstrate that PTPN2-deficient T cells are less dependent on cytokines and show increased programmed expansion, and short-lived effector T cells have enhanced survival and expansion capacity.",

keywords = "GWAS, Protein tyrosine phosphatase non‑receptor type 2 (PTPN2), T cell memory, adoptive T cell transfer, autoimmunity, effector T cells, immunotherapy, phosphoproteome, programmed T cell expansion, single point mutation",

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doi = "10.1016/j.celrep.2020.107957",

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AU - Flosbach, Markus

AU - Oberle, Susanne G.

AU - Scherer, Stefanie

AU - Zecha, Jana

AU - von Hoesslin, Madlaina

AU - Wiede, Florian

AU - Chennupati, Vijaykumar

AU - Cullen, Jolie G.

AU - List, Markus

AU - Pauling, Josch K.

AU - Baumbach, Jan

AU - Kuster, Bernhard

AU - Tiganis, Tony

AU - Zehn, Dietmar

PY - 2020/7/28

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AB - Manipulating PTPN2 has potential for advancing immunotherapies. However, it is unclear how PTPN2 impacts the activation, survival, and memory formation of T cells. Flosbach et al. demonstrate that PTPN2-deficient T cells are less dependent on cytokines and show increased programmed expansion, and short-lived effector T cells have enhanced survival and expansion capacity.

KW - GWAS

KW - Protein tyrosine phosphatase non‑receptor type 2 (PTPN2)

KW - T cell memory

KW - adoptive T cell transfer

KW - autoimmunity

KW - effector T cells

KW - immunotherapy

KW - phosphoproteome

KW - programmed T cell expansion

KW - single point mutation

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JO - Cell Reports

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ER -

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Abstract

Keywords

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