TY - JOUR
T1 - Psoriasin (S100A7) up-regulation in oral squamous cell carcinoma and its relation to clinicopathologic features
AU - Kesting, Marco Rainer
AU - Sudhoff, Holger
AU - Hasler, Rafael Johannes
AU - Nieberler, Markus
AU - Pautke, Christoph
AU - Wolff, Klaus Dietrich
AU - Wagenpfeil, Stefan
AU - Al-Benna, Sammy
AU - Jacobsen, Frank
AU - Steinstraesser, Lars
PY - 2009/8
Y1 - 2009/8
N2 - Proteomic analysis recently suggested aberrant psoriasin (S100A7) expression in oral squamous cell carcinoma (OSCC). In this study, OSCC specimens and matching normal oral tissues from 45 patients who had undergone ablative surgery were examined. Increased psoriasin expression at mRNA level was observed in OSCC samples by quantitative real-time RT-PCR (p = 0.015). Immunoflourescence analysis with psoriasin antibody confirmed these observations. Moreover, significantly increased mRNA ratios between malignant and normal samples were correlated with early UICC stage (p = 0.006), T1/T2 tumour classification (p = 0.043), absence of cervical lymph node metastasis (p = 0.027) and age under 65 (p = 0.009). Additionally, well-differentiated tumour tissues demonstrated a significantly higher psoriasin expression than moderate and poor differentiated carcinomas (p = 0.018). Based on this data, we conclude that psoriasin is a positive marker for oral cancerogenesis and early tumour progression.
AB - Proteomic analysis recently suggested aberrant psoriasin (S100A7) expression in oral squamous cell carcinoma (OSCC). In this study, OSCC specimens and matching normal oral tissues from 45 patients who had undergone ablative surgery were examined. Increased psoriasin expression at mRNA level was observed in OSCC samples by quantitative real-time RT-PCR (p = 0.015). Immunoflourescence analysis with psoriasin antibody confirmed these observations. Moreover, significantly increased mRNA ratios between malignant and normal samples were correlated with early UICC stage (p = 0.006), T1/T2 tumour classification (p = 0.043), absence of cervical lymph node metastasis (p = 0.027) and age under 65 (p = 0.009). Additionally, well-differentiated tumour tissues demonstrated a significantly higher psoriasin expression than moderate and poor differentiated carcinomas (p = 0.018). Based on this data, we conclude that psoriasin is a positive marker for oral cancerogenesis and early tumour progression.
KW - Age
KW - Clinicopathologic correlation
KW - Oral squamous cell carcinoma
KW - Psoriasin
KW - Recurrence
KW - S100A7
KW - Stage
UR - http://www.scopus.com/inward/record.url?scp=67650476228&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2008.11.012
DO - 10.1016/j.oraloncology.2008.11.012
M3 - Article
C2 - 19147391
AN - SCOPUS:67650476228
SN - 1368-8375
VL - 45
SP - 731
EP - 736
JO - Oral Oncology
JF - Oral Oncology
IS - 8
ER -
