Proteome analysis suggests that mitochondrial dysfunction in stressed endothelial cells is reversed by a soy extract and isolated isoflavones

Dagmar Fuchs, Barbara Dirscherl, Joyce H. Schroot, Hannelore Daniel, Uwe Wenzel

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Apoptosis is a driving force in atherosclerosis development. A soy extract or a combination of the soy isoflavones genistein and daidzein inhibited apoptosis induced by oxidized LDL in endothelial cells. Proteome analysis revealed that the LDL-induced alterations of numerous proteins were reversed by the extract and the genistein/daidzein mixture but only three protein entities, all functionally linked to mitochondrial dysfunction, were regulated in common by both treatments.

Original languageEnglish
Pages (from-to)2132-2142
Number of pages11
JournalJournal of Proteome Research
Volume6
Issue number6
DOIs
StatePublished - Jun 2007

Keywords

  • Apoptosis
  • Atherosclerosis
  • Proteomics
  • Reactive oxygen species
  • ox-LDL

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