Abstract
Apoptosis is a driving force in atherosclerosis development. A soy extract or a combination of the soy isoflavones genistein and daidzein inhibited apoptosis induced by oxidized LDL in endothelial cells. Proteome analysis revealed that the LDL-induced alterations of numerous proteins were reversed by the extract and the genistein/daidzein mixture but only three protein entities, all functionally linked to mitochondrial dysfunction, were regulated in common by both treatments.
Original language | English |
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Pages (from-to) | 2132-2142 |
Number of pages | 11 |
Journal | Journal of Proteome Research |
Volume | 6 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2007 |
Keywords
- Apoptosis
- Atherosclerosis
- Proteomics
- Reactive oxygen species
- ox-LDL