Protection from alcohol intoxication: Must be FGF21 to enter

Martin Jastroch; Susanne Keipert; Matthias H. Tschöp

doi:10.1016/j.cmet.2023.02.010

Protection from alcohol intoxication: Must be FGF21 to enter

Martin Jastroch
, Susanne Keipert
, Matthias H. Tschöp

Medicine and Health

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Fibroblast growth factor 21 (FGF21) is generally known as a stress-induced metabolic regulator with enormous therapeutic potential to treat metabolic diseases, but a more specific role of FGF21 concerns physiological handling of alcohol in mammals. In this issue of Cell Metabolism, Choi et al. demonstrate that FGF21 mediates the recovery from alcohol intoxication by directly activating noradrenergic neurons in mice, thus advancing our knowledge on FGF21 biology and further diversifying its therapeutic potential.

Original language	English
Pages (from-to)	377-379
Number of pages	3
Journal	Cell Metabolism
Volume	35
Issue number	3
DOIs	https://doi.org/10.1016/j.cmet.2023.02.010
State	Published - 7 Mar 2023

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10.1016/j.cmet.2023.02.010

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title = "Protection from alcohol intoxication: Must be FGF21 to enter",

abstract = "Fibroblast growth factor 21 (FGF21) is generally known as a stress-induced metabolic regulator with enormous therapeutic potential to treat metabolic diseases, but a more specific role of FGF21 concerns physiological handling of alcohol in mammals. In this issue of Cell Metabolism, Choi et al. demonstrate that FGF21 mediates the recovery from alcohol intoxication by directly activating noradrenergic neurons in mice, thus advancing our knowledge on FGF21 biology and further diversifying its therapeutic potential.",

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AU - Keipert, Susanne

AU - Tschöp, Matthias H.

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N2 - Fibroblast growth factor 21 (FGF21) is generally known as a stress-induced metabolic regulator with enormous therapeutic potential to treat metabolic diseases, but a more specific role of FGF21 concerns physiological handling of alcohol in mammals. In this issue of Cell Metabolism, Choi et al. demonstrate that FGF21 mediates the recovery from alcohol intoxication by directly activating noradrenergic neurons in mice, thus advancing our knowledge on FGF21 biology and further diversifying its therapeutic potential.

AB - Fibroblast growth factor 21 (FGF21) is generally known as a stress-induced metabolic regulator with enormous therapeutic potential to treat metabolic diseases, but a more specific role of FGF21 concerns physiological handling of alcohol in mammals. In this issue of Cell Metabolism, Choi et al. demonstrate that FGF21 mediates the recovery from alcohol intoxication by directly activating noradrenergic neurons in mice, thus advancing our knowledge on FGF21 biology and further diversifying its therapeutic potential.

UR - https://www.scopus.com/pages/publications/85149686630

U2 - 10.1016/j.cmet.2023.02.010

DO - 10.1016/j.cmet.2023.02.010

M3 - Comment/debate

C2 - 36889276

AN - SCOPUS:85149686630

SN - 1550-4131

VL - 35

SP - 377

EP - 379

JO - Cell Metabolism

JF - Cell Metabolism

IS - 3

ER -

Protection from alcohol intoxication: Must be FGF21 to enter

Abstract

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