TY - JOUR
T1 - Prostate-specific Membrane Antigen Positron Emission Tomography–detected Oligorecurrent Prostate Cancer Treated with Metastases-directed Radiotherapy
T2 - Role of Addition and Duration of Androgen Deprivation
AU - Kroeze, Stephanie G.C.
AU - Henkenberens, Christoph
AU - Schmidt-Hegemann, Nina Sophie
AU - Vogel, Marco M.E.
AU - Kirste, Simon
AU - Becker, Jessica
AU - Burger, Irene A.
AU - Derlin, Thorsten
AU - Bartenstein, Peter
AU - Eiber, Matthias
AU - Mix, Michael
AU - la Fougère, Christian
AU - Christiansen, Hans
AU - Belka, Claus
AU - Combs, Stephanie E.
AU - Grosu, Anca L.
AU - Müller, Arndt Christian
AU - Guckenberger, Matthias
N1 - Publisher Copyright:
© 2019 European Association of Urology
PY - 2021/3
Y1 - 2021/3
N2 - Background: Approximately 40–70% of biochemically recurrent prostate cancer (PCa) is oligorecurrent after prostate-specific membrane antigen (PSMA) positron emission tomography (PET) staging. Metastasis-directed radiotherapy (MDT) of PSMA-positive oligorecurrence is now frequently used, but the role of concurrent androgen deprivation therapy (ADT) remains unclear. Objective: To determine the effect of concurrent ADT with PSMA PET–directed MDT on biochemical progression-free survival (bRFS). Design, setting, and participants: This was a retrospective multicenter study of 305 patients with biochemical recurrence and PSMA PET–positive oligorecurrence following initial curative treatment between April 2013 and January 2018. Intervention: MDT with fractionated or stereotactic body radiotherapy for all PSMA-positive metastatic sites; 37.8% received concurrent ADT. Outcome measurements and statistical analysis: The primary outcome was bRFS, which was measured using Kaplan-Meier curves and log-rank testing. Secondary outcomes were ADT-free survival, overall survival (OS), and toxicity was analyzed using the Common Terminology Criteria for Adverse Events v4.03. Univariate and multivariate analyses were performed to determine independent clinicopathological factors. Results and limitations: The median follow-up was 16 mo (interquartile range 9–27). Some 96% of the patients initially had high-risk PCa. A median of one (range 0–19) nodal metastases and one (range 0–5) distant metastases were treated. MDT + ADT significantly improved bRFS and remained an independent factor (hazard ratio 0.28, 95% confidence interval 0.16–0.51; p < 0.0001). bRFS was not significantly different between MDT + ≤6 mo of ADT and MDT alone (p = 0.121). Patients receiving MDT had 1- and 2-yr ADT-free survival of 93% and 83%, respectively. New therapies, most frequently MDT (23%), were required more frequently after MDT (85% vs 29%; p < 0.001). Grade ≥3 acute toxicity was observed in 0.9% of patients and late toxicity in 2.3%. Conclusions: In this cohort of patients with oligorecurrent PCa, concurrent ADT with MDT improved bRFS significantly, but a large number of patients treated with MDT were spared from ADT for 2 yr, although a greater need for other salvage therapies was observed. Patient summary: The role of concurrent androgen deprivation therapy (ADT) with radiotherapy for prostate cancer oligorecurrence identified on prostate-specific membrane antigen positron emission tomography was studied. We concluded that radiotherapy alone could prolong the time to start of ADT. However, the risk of disease progression and consequently the need for further treatments is higher after local radiotherapy alone without immediate ADT.Metastases-directed therapy (MDT) of prostate-specific membrane messaging positron emission tomography–positive oligorecurrent prostate cancer is associated with a higher rate of biochemical recurrence compared to MDT with concurrent androgen deprivation therapy (ADT). However, initiation of ADT could be delayed in the majority of patients after MDT alone.
AB - Background: Approximately 40–70% of biochemically recurrent prostate cancer (PCa) is oligorecurrent after prostate-specific membrane antigen (PSMA) positron emission tomography (PET) staging. Metastasis-directed radiotherapy (MDT) of PSMA-positive oligorecurrence is now frequently used, but the role of concurrent androgen deprivation therapy (ADT) remains unclear. Objective: To determine the effect of concurrent ADT with PSMA PET–directed MDT on biochemical progression-free survival (bRFS). Design, setting, and participants: This was a retrospective multicenter study of 305 patients with biochemical recurrence and PSMA PET–positive oligorecurrence following initial curative treatment between April 2013 and January 2018. Intervention: MDT with fractionated or stereotactic body radiotherapy for all PSMA-positive metastatic sites; 37.8% received concurrent ADT. Outcome measurements and statistical analysis: The primary outcome was bRFS, which was measured using Kaplan-Meier curves and log-rank testing. Secondary outcomes were ADT-free survival, overall survival (OS), and toxicity was analyzed using the Common Terminology Criteria for Adverse Events v4.03. Univariate and multivariate analyses were performed to determine independent clinicopathological factors. Results and limitations: The median follow-up was 16 mo (interquartile range 9–27). Some 96% of the patients initially had high-risk PCa. A median of one (range 0–19) nodal metastases and one (range 0–5) distant metastases were treated. MDT + ADT significantly improved bRFS and remained an independent factor (hazard ratio 0.28, 95% confidence interval 0.16–0.51; p < 0.0001). bRFS was not significantly different between MDT + ≤6 mo of ADT and MDT alone (p = 0.121). Patients receiving MDT had 1- and 2-yr ADT-free survival of 93% and 83%, respectively. New therapies, most frequently MDT (23%), were required more frequently after MDT (85% vs 29%; p < 0.001). Grade ≥3 acute toxicity was observed in 0.9% of patients and late toxicity in 2.3%. Conclusions: In this cohort of patients with oligorecurrent PCa, concurrent ADT with MDT improved bRFS significantly, but a large number of patients treated with MDT were spared from ADT for 2 yr, although a greater need for other salvage therapies was observed. Patient summary: The role of concurrent androgen deprivation therapy (ADT) with radiotherapy for prostate cancer oligorecurrence identified on prostate-specific membrane antigen positron emission tomography was studied. We concluded that radiotherapy alone could prolong the time to start of ADT. However, the risk of disease progression and consequently the need for further treatments is higher after local radiotherapy alone without immediate ADT.Metastases-directed therapy (MDT) of prostate-specific membrane messaging positron emission tomography–positive oligorecurrent prostate cancer is associated with a higher rate of biochemical recurrence compared to MDT with concurrent androgen deprivation therapy (ADT). However, initiation of ADT could be delayed in the majority of patients after MDT alone.
KW - Antiandrogen therapy
KW - Concurrent
KW - Oligometastases
KW - Prostate cancer
KW - Prostate-specific membrane antigen
KW - Radiotherapy
KW - Recurrence
KW - Stereotactic
UR - http://www.scopus.com/inward/record.url?scp=85071722321&partnerID=8YFLogxK
U2 - 10.1016/j.euf.2019.08.012
DO - 10.1016/j.euf.2019.08.012
M3 - Article
C2 - 31495759
AN - SCOPUS:85071722321
SN - 2405-4569
VL - 7
SP - 309
EP - 316
JO - European Urology Focus
JF - European Urology Focus
IS - 2
ER -