Prospektive Verlaufsbeobachtungsstudien zur Entstehung des Typ-1-Diabetes im Kindesalter und während der Pubertät

Translated title of the contribution: Prospective observational studies of the development of type 1 diabetes during childhood and puberty

F. Meier-Stiegen, A. G. Ziegler

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The incidence of type 1 diabetes is increasing rapidly. Detecting the mechanisms underlying the autoimmune disease is a main goal of research. Studies investigating the pathogenesis of type 1 diabetes are working on the identification and characterization of exogenous, endogenous and genetic factors which induce or modify autoimmunity. Islet cell autoimmunity can be detected through screening for islet cell autoantibodies. This quantitative analysis allows the stratification of the individual risk for the development of type 1 diabetes. Prospective observational studies are most suitable to assess persons at risk, either because of the occurence of type 1 diabetes in the familiy or because of a genotype associated with increased risk. Age-related factors which are analysed in observational studies include nutrition, increase in height and weight, childhood diseases and vaccinations as well as psychosocial aspects. Identification and charakterization of these risk factors will serve as a basis for working on new approaches to prevent or to cure type 1 diabetes. Aim of this article is to provide an overview of the most relevant observational studies.

Translated title of the contributionProspective observational studies of the development of type 1 diabetes during childhood and puberty
Original languageGerman
Pages (from-to)271-275
Number of pages5
JournalDeutsche Medizinische Wochenschrift
Volume136
Issue number6
DOIs
StatePublished - 2011
Externally publishedYes

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