TY - JOUR
T1 - Prominent hypometabolism of the right temporoparietal and frontal cortex in two left-handed patients with primary progressive aphasia
AU - Drzezga, Alexander
AU - Grimmer, Timo
AU - Siebner, Hartwig
AU - Minoshima, Satoshi
AU - Schwaiger, Markus
AU - Kurz, Alexander
PY - 2002
Y1 - 2002
N2 - Primary progressive aphasia (PPA) is characterized by progressive deterioration of language function with relative preservation of other cognitive functions. Previous studies based on neuroimaging and histology point to predominantly left temporal pathology in PPA patients. Here we report two left-handed subjects with typical symptoms of the non-fluent form of PPA in whom 18F-FDG PET revealed an asymmetric right-hemispheric pattern of reduced glucose metabolism in the frontal and temporoparietal cortex. These findings support the hypothesis that PPA can be considered as a symptom complex rather than a disease entity.
AB - Primary progressive aphasia (PPA) is characterized by progressive deterioration of language function with relative preservation of other cognitive functions. Previous studies based on neuroimaging and histology point to predominantly left temporal pathology in PPA patients. Here we report two left-handed subjects with typical symptoms of the non-fluent form of PPA in whom 18F-FDG PET revealed an asymmetric right-hemispheric pattern of reduced glucose metabolism in the frontal and temporoparietal cortex. These findings support the hypothesis that PPA can be considered as a symptom complex rather than a disease entity.
KW - Left-handedness
KW - Positron Emission Tomography
KW - Primary progressive aphasia
KW - Regional cerebral metabolism
UR - http://www.scopus.com/inward/record.url?scp=0036042276&partnerID=8YFLogxK
U2 - 10.1007/s00415-002-0832-z
DO - 10.1007/s00415-002-0832-z
M3 - Article
C2 - 12242551
AN - SCOPUS:0036042276
SN - 0340-5354
VL - 249
SP - 1263
EP - 1267
JO - Journal of Neurology
JF - Journal of Neurology
IS - 9
ER -