PROLIFERATIONS-INDEX, AXILLARER LYMPHOKNOTENSTATUS, HORMONREZEPTOREN UND ALTER ALS PROGNOSEFAKTOREN BEIM PRIMAREN MAMMAKARZINOM

Translated title of the contribution: Proliferation index, axillary lymph node status, hormone receptors and age as prognostic factors in primary carcinoma of the breast

M. Kaufmann, K. Klinga, W. Kuhn, U. Abel

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A total of 233 primary carcinomas of the breast (n = 68 nodal negative and n = 165 nodal positive) of 77 women patients of less than 50 years of age and of 156 women patients of 50 years of age or older were examined for the prognostic significance of a proliferation index (in vitro chemoresistance assay). The prognostic significance of the proliferation index (high vs low proliferation) is compared with other prognostic factors that have already been in clinical use (age, axillary lymph node status, oestrogen and progesterone receptor status). The total median observation period was 4.8 years (3-9.1 years). Determination of the proliferation index proved to be the most important prognostic factor both for premenopausal and postmenopausal, nodal negative and nodal positive primary tumours when assessing the total survival time and the time that remains free from recurrences. A simultaneous assessment of low proliferation index and positive hormone receptor as a so-called low-risk situation shows in comparison to a high-risk situation (high proliferation index, negative receptor status) the most pronounced differences. For premenopausal women (younger than 50 years of age) the hormone receptor status has no prognostic significance as far as our group of patients is concerned, whereas for women of 50 years of age or older the receptor status is of great prognostic relevance. Besides the lymph node status, the proliferation index shows in a Cox regression model the greatest prognostic importance for the further course of a primary carcinoma of the breast. Hence, this factor should be used as a prognostic selection criterion for defining low-risk and high-risk patients in primary carcinoma of the breast during controlled randomised therapy studies.

Translated title of the contributionProliferation index, axillary lymph node status, hormone receptors and age as prognostic factors in primary carcinoma of the breast
Original languageGerman
Pages (from-to)104-108
Number of pages5
JournalGeburtshilfe und Frauenheilkunde
Volume49
Issue numberSUPPL. 1
DOIs
StatePublished - 1989
Externally publishedYes

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