TY - JOUR
T1 - Proliferating cell nuclear antigen (PCNA) in atypical and malignant meningiomas
AU - Zimmer, C.
AU - Gottschalk, J.
AU - Cervos-Navarro, J.
AU - Martin, H.
AU - Beil, M.
AU - Jautzke, G.
PY - 1992
Y1 - 1992
N2 - Because it is not easy to determine the tumor status o f meningiomas by current diagnostic procedures, we investigated these tumors immunohistochemically using the monoclonal antibody PC 10. This antibody recognizes a fixation- and processing-resistant epitope o f the proliferating cell nuclear antigen (PCNA), which is a 36-KD nuclear antigen associated with the cell cycle. We studied paraffin-embedded and f ormalin-fixed tissue specimens o f a group o f 21 atypicallmalignant meningiomas together with 18 benign meningiomas. PCNA staining results were compared with -the mean number o f silver-stained nucleolar organizer region-associated proteins (AgNORs), tumor grading, and mitotic indices o f these tumors. The percentage o f PCNA-positive cells was found to range between 0.1 and 40%, irrespective o f the tumor grade. When all tumors were collectively considered, no positive correlation was found between PCNA scores and histologic grading and only a weak one between PCNA score and mitotic index. A higher correlation was seen between AgNOR counts and tumor grading. Our results suggest that PCNA labeling and histologic grading seem to be independent parameters. The correlations found between AgNOR counts and tumor grading should be substantiated in further series.
AB - Because it is not easy to determine the tumor status o f meningiomas by current diagnostic procedures, we investigated these tumors immunohistochemically using the monoclonal antibody PC 10. This antibody recognizes a fixation- and processing-resistant epitope o f the proliferating cell nuclear antigen (PCNA), which is a 36-KD nuclear antigen associated with the cell cycle. We studied paraffin-embedded and f ormalin-fixed tissue specimens o f a group o f 21 atypicallmalignant meningiomas together with 18 benign meningiomas. PCNA staining results were compared with -the mean number o f silver-stained nucleolar organizer region-associated proteins (AgNORs), tumor grading, and mitotic indices o f these tumors. The percentage o f PCNA-positive cells was found to range between 0.1 and 40%, irrespective o f the tumor grade. When all tumors were collectively considered, no positive correlation was found between PCNA scores and histologic grading and only a weak one between PCNA score and mitotic index. A higher correlation was seen between AgNOR counts and tumor grading. Our results suggest that PCNA labeling and histologic grading seem to be independent parameters. The correlations found between AgNOR counts and tumor grading should be substantiated in further series.
KW - Malignant meningioma
KW - Mitotic index
KW - Nucleolar organizer region proteins
KW - Proliferating cell nuclear antigen
KW - Proliferative activity
UR - http://www.scopus.com/inward/record.url?scp=0027064592&partnerID=8YFLogxK
U2 - 10.1016/S0344-0338(11)81237-9
DO - 10.1016/S0344-0338(11)81237-9
M3 - Article
C2 - 1363764
AN - SCOPUS:0027064592
SN - 0344-0338
VL - 188
SP - 951
EP - 958
JO - Pathology Research and Practice
JF - Pathology Research and Practice
IS - 8
ER -