Abstract
Recently, motor neurones of the myenteric plexus innervating the muscle layers or the mucosa have been identified in the guinea-pig stomach. We applied the neuronal tracer Dil (1,1'-didodecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorat) onto myenteric ganglia in order to identify populations of interneurones in the myenteric plexus of the guinea-pig stomach. The tracing was combined with the immunohistochemical detection of calbindinD28k (CALB), choline acetyltransferase (ChAT), neuropeptide Y (NPY) and 5-hydroxytryptamine (serotonin) (5-HT) and the results were compared to the neurochemical coding of target specific motor neurones. Long projecting (~5.4 mm) ChAT/CALB/±5-HT-, nitric oxide synthase (NOS)/CALB- and short projecting (~1.1 mm) ChAT/NPY-neurones were identified as descending interneurones. CALB positive ascending interneurones contained ChAT but rarely 5-HT (code: ChAT/CALB). This study identified ascending and descending interneurones in the gastric myenteric plexus and revealed the neurochemical coding of some of the interneurone populations. (C) 2000 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 109-112 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 295 |
| Issue number | 3 |
| DOIs | |
| State | Published - 8 Dec 2000 |
| Externally published | Yes |
Keywords
- Calbindin
- Enteric nervous system
- Gastric myenteric plexus
- Interneurones
- Neurochemical coding
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