TY - JOUR
T1 - Progression of aortic pulse wave velocity in patients with chronic kidney disease
AU - Tholen, Susanne
AU - Klofat, Katharina
AU - Pan, Cheng Rui
AU - Schmaderer, Christoph
AU - Lutz, Jens
AU - Heemann, Uwe
AU - Baumann, Marcus
PY - 2013/11
Y1 - 2013/11
N2 - Aortic pulse wave velocity (aPWV) is elevated in patients with chronic kidney disease (CKD) and predicts cardiovascular risk. However, the natural progression of arterial stiffness in these patients remains uncertain. Therefore, the main aim of this study was to investigate the development of aPWV and to identify potential factors associated with its progression. aPWV measurement was carried out in 70 CKD patients at baseline and after 12 months. Correlations to several variables, in particular annual glomerular filtration rate reduction and diabetes mellitus, were studied. In the cohort, aPWV significantly increased in 1 year by 1.1 m/s (P<.01). Dividing the group into patients with stable and progressive aPWV, factors associated with accelerated progression were age, systolic blood pressure, and diabetes, whereas loss of renal function had no significant impact. The annual aPWV progression in CKD patients reached 1 m/s, which predicts an increased cardiovascular risk. Variables involved with progressive arterial stiffness need further evaluation.
AB - Aortic pulse wave velocity (aPWV) is elevated in patients with chronic kidney disease (CKD) and predicts cardiovascular risk. However, the natural progression of arterial stiffness in these patients remains uncertain. Therefore, the main aim of this study was to investigate the development of aPWV and to identify potential factors associated with its progression. aPWV measurement was carried out in 70 CKD patients at baseline and after 12 months. Correlations to several variables, in particular annual glomerular filtration rate reduction and diabetes mellitus, were studied. In the cohort, aPWV significantly increased in 1 year by 1.1 m/s (P<.01). Dividing the group into patients with stable and progressive aPWV, factors associated with accelerated progression were age, systolic blood pressure, and diabetes, whereas loss of renal function had no significant impact. The annual aPWV progression in CKD patients reached 1 m/s, which predicts an increased cardiovascular risk. Variables involved with progressive arterial stiffness need further evaluation.
UR - http://www.scopus.com/inward/record.url?scp=84886946238&partnerID=8YFLogxK
U2 - 10.1111/jch.12198
DO - 10.1111/jch.12198
M3 - Article
C2 - 24102750
AN - SCOPUS:84886946238
SN - 1524-6175
VL - 15
SP - 833
EP - 838
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
IS - 11
ER -