Progress in the Palladium-Catalyzed α-Arylation of Ketones with Chloroarenes

Andreas Ehrentraut, Alexander Zapf, Matthias Beller

Research output: Contribution to journalArticlepeer-review

163 Scopus citations


Non- and deactivated chloroarenes can be coupled with a wide range of ketones to yield the corresponding arylmethyl ketones in good to excellent yields using a palladium(II) acetate/n-BuPAd2 catalyst system. Depending on the ketone, the chloroarene/ketone ratio and the base, mono or diarylation can be effected selectively.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalAdvanced Synthesis and Catalysis
Issue number2
StatePublished - Apr 2002
Externally publishedYes


  • Aryl chlorides
  • Arylation
  • Homogeneous catalysis
  • Ketones
  • Palladium


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