Prognostic significance of AGR2 in pancreatic ductal adenocarcinoma

Marc Oliver Riener, Christian Pilarsky, Josefine Gerhardt, Robert Grützmann, Florian R. Fritzsche, Marcus Bahra, Wilko Weichert, Glen Kristiansen

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Background/Aims: The human Anterior Gradient-2 (AGR2) is strongly upregulated in various human cancers, including pancreatic ductal adenocarcinomas (PDAC), but its prognostic value in PDAC has not yet been studied. Methods: We analysed 19 microdissected PDAC cases at the mRNA level, and also 148 cases at the protein level by immunohistochemistry based on tissue microarray, using a monoclonal AGR2 antibody, and statistical analyses were applied to test for prognostic associations. Results: Overexpression of AGR2 mRNA was found to be elevated in most pancreatic cell lines and in microdissected pancreatic cancer compared to microdissected normal ductal cells. AGR2 protein was expressed in 109/148 (73.7%) of PDAC, with a higher expression in female patients (p=0.040), whereas no significant associations with other clinical-pathological parameters were found. A prognostic value of AGR2 could not be demonstrated in univariate analyses. Conclusion: Although a prognostic value of AGR2 seems unlikely, further studies are warranted to investigate the biological role of AGR2 in pancreatic adenocarcinomas.

Original languageEnglish
Pages (from-to)1121-1128
Number of pages8
JournalHistology and Histopathology
Volume24
Issue number9
StatePublished - Sep 2009
Externally publishedYes

Keywords

  • AGR2
  • Immunohistochemistry
  • Pancreatic adenocarcinoma
  • Prognosis
  • mRNA

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