Prognostic factors in ALS: a comparison between Germany and China

Johannes Dorst, Lu Chen, Angela Rosenbohm, Jens Dreyhaupt, Annemarie Hübers, Joachim Schuster, Jochen H. Weishaupt, Jan Kassubek, Burkhard Gess, Thomas Meyer, Ute Weyen, Andreas Hermann, Jürgen Winkler, Torsten Grehl, Tim Hagenacker, Paul Lingor, Jan C. Koch, Anne Sperfeld, Susanne Petri, Julian GroßkreutzMoritz Metelmann, Joachim Wolf, Andrea S. Winkler, Thomas Klopstock, Matthias Boentert, Siw Johannesen, Alexander Storch, Bertold Schrank, Daniel Zeller, Xiao lu Liu, Lu Tang, Dong Sheng Fan, Albert C. Ludolph

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Objective: Several independent prognostic factors, such as age of onset, type of onset, body mass index (BMI), and progression rate have been identified for amyotrophic lateral sclerosis (ALS) in Caucasians. The aim of this study was to identify such factors in Chinese patients and to compare their impact with German patients. Methods: Comparison of prognostic factors was based on two hospital-based registries. The registry of the German Network for Motor Neuron Diseases contains 3100 patients with ALS. The Chinese registry comprises 2101 patients who were collected between 2003 and 2015 in the metropolitan area of Beijing. Results: Disease progression was slower in China [median loss of 0.50 points (IQR 0.26–0.87 points) versus 0.55 points (IQR 0.28–1.00 points) of ALS functional rating scale revised (ALS-FRS-R) score per month; p < 0.0001]. Survival of patients with ALS was similar in Germany and China (p > 0.05). We found that younger age of onset (p < 0.0001), spinal onset (p < 0.0001), high BMI (p < 0.0001) and low progression rate (p < 0.0001) were positive prognostic factors in China as well as in Germany. Interpretation: Prognostic factors, which are known to modify the course of disease in Caucasians, apply to Chinese patients as well. The results indicate that despite the apparent differences regarding genotype and clinical phenotype, findings from interventional studies in Caucasians aiming at disease-modifying prognostic factors (such as body weight) may be transferred to Chinese patients.

Original languageEnglish
JournalJournal of Neurology
DOIs
StateAccepted/In press - 2019
Externally publishedYes

Keywords

  • Amyotrophic lateral sclerosis
  • China
  • Germany
  • Motor neuron disease
  • Prognostic factors
  • Survival

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