Profiling the annual change of the neurobiological and antioxidant effects of five Origanum species in correlation with their phytochemical composition

Hasya Nazli Gök; Simon Vlad Luca; Saadet Tugrul Ay; Łukasz Komsta; Ramin Ekhteiari Salmas; Ilkay Erdogan Orhan; Krystyna Skalicka-Woźniak

doi:10.1016/j.foodchem.2021.130775

Profiling the annual change of the neurobiological and antioxidant effects of five Origanum species in correlation with their phytochemical composition

Hasya Nazli Gök, Simon Vlad Luca, Saadet Tugrul Ay, Łukasz Komsta, Ramin Ekhteiari Salmas, Ilkay Erdogan Orhan, Krystyna Skalicka-Woźniak

Associate Professorship of Biothermodynamics

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The ethanol extracts of five Origanum species: O. majorana L., O. onites L., O. syriacum L., O. vulgare subsp. hirtum (Link) Ietsw., and O. vulgare subsp. viride (Boiss.) Hayek, collected annually (each month), were investigated for their cholinesterase inhibition and antioxidant effects. The phytochemical composition of a total of 60 extracts was assessed by HPLC-DAD-ESI/HRMS, revealing the presence of a total of 73 compounds. Possible correlation between the bioactivity and metabolite profiles during 12 months was monitored. Acetylcholinesterase (AChE) inhibitory activity was found to be the highest between April and November (50.29–75.95%, 200 μg/mL), while the highest inhibition towards butyrylcholinesterase (BChE) was observed for the extracts between April and October (71.68–88.97%). Aromadendrin showed good correlation with anti-AChE, anti-BChE and reducing power activities. Furthermore, molecular docking data with aromadendrin, caffeoylarbutin and eriodictyol indicated that caffeoylarbutin had the lowest binding energy against both enzymes.

Original language	English
Article number	130775
Journal	Food Chemistry
Volume	368
DOIs	https://doi.org/10.1016/j.foodchem.2021.130775
State	Published - 30 Jan 2022

Keywords

Antioxidant
Cholinesterase
Correlation
HPLC-DAD-ESI/HRMS
Oregano
Origanum

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10.1016/j.foodchem.2021.130775

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title = "Profiling the annual change of the neurobiological and antioxidant effects of five Origanum species in correlation with their phytochemical composition",

abstract = "The ethanol extracts of five Origanum species: O. majorana L., O. onites L., O. syriacum L., O. vulgare subsp. hirtum (Link) Ietsw., and O. vulgare subsp. viride (Boiss.) Hayek, collected annually (each month), were investigated for their cholinesterase inhibition and antioxidant effects. The phytochemical composition of a total of 60 extracts was assessed by HPLC-DAD-ESI/HRMS, revealing the presence of a total of 73 compounds. Possible correlation between the bioactivity and metabolite profiles during 12 months was monitored. Acetylcholinesterase (AChE) inhibitory activity was found to be the highest between April and November (50.29–75.95%, 200 μg/mL), while the highest inhibition towards butyrylcholinesterase (BChE) was observed for the extracts between April and October (71.68–88.97%). Aromadendrin showed good correlation with anti-AChE, anti-BChE and reducing power activities. Furthermore, molecular docking data with aromadendrin, caffeoylarbutin and eriodictyol indicated that caffeoylarbutin had the lowest binding energy against both enzymes.",

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AU - Luca, Simon Vlad

AU - Ay, Saadet Tugrul

AU - Komsta, Łukasz

AU - Salmas, Ramin Ekhteiari

AU - Orhan, Ilkay Erdogan

AU - Skalicka-Woźniak, Krystyna

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AB - The ethanol extracts of five Origanum species: O. majorana L., O. onites L., O. syriacum L., O. vulgare subsp. hirtum (Link) Ietsw., and O. vulgare subsp. viride (Boiss.) Hayek, collected annually (each month), were investigated for their cholinesterase inhibition and antioxidant effects. The phytochemical composition of a total of 60 extracts was assessed by HPLC-DAD-ESI/HRMS, revealing the presence of a total of 73 compounds. Possible correlation between the bioactivity and metabolite profiles during 12 months was monitored. Acetylcholinesterase (AChE) inhibitory activity was found to be the highest between April and November (50.29–75.95%, 200 μg/mL), while the highest inhibition towards butyrylcholinesterase (BChE) was observed for the extracts between April and October (71.68–88.97%). Aromadendrin showed good correlation with anti-AChE, anti-BChE and reducing power activities. Furthermore, molecular docking data with aromadendrin, caffeoylarbutin and eriodictyol indicated that caffeoylarbutin had the lowest binding energy against both enzymes.

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Profiling the annual change of the neurobiological and antioxidant effects of five Origanum species in correlation with their phytochemical composition

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Keywords

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