ProfCom: a web tool for profiling the complex functionality of gene groups identified from high-throughput data.

Alexey V. Antonov; Thorsten Schmidt; Y. Wang; Hans W. Mewes

doi:10.1093/nar/gkn239

ProfCom: a web tool for profiling the complex functionality of gene groups identified from high-throughput data.

Alexey V. Antonov, Thorsten Schmidt, Y. Wang, Hans W. Mewes

Helmholtz Zentrum München German Research Center for Environmental Health

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

ProfCom is a web-based tool for the functional interpretation of a gene list that was identified to be related by experiments. A trait which makes ProfCom a unique tool is an ability to profile enrichments of not only available Gene Ontology (GO) terms but also of 'complex functions'. A 'Complex function' is constructed as Boolean combination of available GO terms. The complex functions inferred by ProfCom are more specific in comparison to single terms and describe more accurately the functional role of genes. ProfCom provides a user friendly dialog-driven web page submission available for several model organisms and supports most available gene identifiers. In addition, the web service interface allows the submission of any kind of annotation data. ProfCom is freely available at http://webclu.bio.wzw.tum.de/profcom/.

Original language	English
Pages (from-to)	W347-351
Journal	Nucleic Acids Research
Volume	36
Issue number	Web Server issue
DOIs	https://doi.org/10.1093/nar/gkn239
State	Published - 1 Jul 2008
Externally published	Yes

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10.1093/nar/gkn239

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title = "ProfCom: a web tool for profiling the complex functionality of gene groups identified from high-throughput data.",

abstract = "ProfCom is a web-based tool for the functional interpretation of a gene list that was identified to be related by experiments. A trait which makes ProfCom a unique tool is an ability to profile enrichments of not only available Gene Ontology (GO) terms but also of 'complex functions'. A 'Complex function' is constructed as Boolean combination of available GO terms. The complex functions inferred by ProfCom are more specific in comparison to single terms and describe more accurately the functional role of genes. ProfCom provides a user friendly dialog-driven web page submission available for several model organisms and supports most available gene identifiers. In addition, the web service interface allows the submission of any kind of annotation data. ProfCom is freely available at http://webclu.bio.wzw.tum.de/profcom/.",

author = "Antonov, {Alexey V.} and Thorsten Schmidt and Y. Wang and Mewes, {Hans W.}",

note = "Funding Information: We thank Ulrich Gueldener, Philip Wong for helpful discussions and Michael Strasser for initial technical help at the project beginning. T.S. was supported by the DFG Program {\textquoteleft}Bioinformatics Initiative Munich{\textquoteright}. Funding to pay the Open Access publication charges for this article was provided by Helmholtz Zentrum Munich, German Research Center for Environmental Health.",

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AU - Schmidt, Thorsten

AU - Wang, Y.

AU - Mewes, Hans W.

N1 - Funding Information: We thank Ulrich Gueldener, Philip Wong for helpful discussions and Michael Strasser for initial technical help at the project beginning. T.S. was supported by the DFG Program ‘Bioinformatics Initiative Munich’. Funding to pay the Open Access publication charges for this article was provided by Helmholtz Zentrum Munich, German Research Center for Environmental Health.

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N2 - ProfCom is a web-based tool for the functional interpretation of a gene list that was identified to be related by experiments. A trait which makes ProfCom a unique tool is an ability to profile enrichments of not only available Gene Ontology (GO) terms but also of 'complex functions'. A 'Complex function' is constructed as Boolean combination of available GO terms. The complex functions inferred by ProfCom are more specific in comparison to single terms and describe more accurately the functional role of genes. ProfCom provides a user friendly dialog-driven web page submission available for several model organisms and supports most available gene identifiers. In addition, the web service interface allows the submission of any kind of annotation data. ProfCom is freely available at http://webclu.bio.wzw.tum.de/profcom/.

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ProfCom: a web tool for profiling the complex functionality of gene groups identified from high-throughput data.

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