TY - JOUR
T1 - Problems concerning liquid-liquid extraction of extracellular products directly from fermenter broths
AU - Job, Christopher
AU - Blass, Eckhart
N1 - Funding Information:
The authors gratefully acknowledge the financial support of the Deutsche Forschungsgemeinschaft.
PY - 1994/12
Y1 - 1994/12
N2 - The separation of extracellular fermentation products can be accomplished by liquid-liquid extraction. The direct extraction of products from fermenter broths shows considerable advantages compared with other methods, e.g. low product losses, high product concentrations and low flow rates. Additionally, equipment expenditure is low and in-situ extraction can be used as a means of manipulating the fermentation process. However, there are also disadvantages, mainly due to the specific properties of fermenter broths. High viscosities and the presence of cells affect the hydrodynamic behaviour of the two-phase system in the extractor. Other problems arise from the prevention of mass transfer and in the selection of solvents for in-situ extraction.
AB - The separation of extracellular fermentation products can be accomplished by liquid-liquid extraction. The direct extraction of products from fermenter broths shows considerable advantages compared with other methods, e.g. low product losses, high product concentrations and low flow rates. Additionally, equipment expenditure is low and in-situ extraction can be used as a means of manipulating the fermentation process. However, there are also disadvantages, mainly due to the specific properties of fermenter broths. High viscosities and the presence of cells affect the hydrodynamic behaviour of the two-phase system in the extractor. Other problems arise from the prevention of mass transfer and in the selection of solvents for in-situ extraction.
UR - http://www.scopus.com/inward/record.url?scp=0028675030&partnerID=8YFLogxK
U2 - 10.1016/0923-0467(94)87025-X
DO - 10.1016/0923-0467(94)87025-X
M3 - Article
AN - SCOPUS:0028675030
SN - 0923-0467
VL - 56
SP - B1
JO - The Chemical Engineering Journal and The Biochemical Engineering Journal
JF - The Chemical Engineering Journal and The Biochemical Engineering Journal
IS - 1
ER -