Probing transient non-native states in amyloid beta fiber elongation by NMR

Jeffrey R. Brender, Anirban Ghosh, Samuel A. Kotler, Janarthanan Krishnamoorthy, Swapna Bera, Vanessa Morris, Timir Baran Sil, Kanchan Garai, Bernd Reif, Anirban Bhunia, Ayyalusamy Ramamoorthy

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Using NMR to probe transient binding of Aβ1-40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues 16-21) currently used for inhibitor design.

Original languageEnglish
Pages (from-to)4483-4486
Number of pages4
JournalChemical Communications
Volume55
Issue number31
DOIs
StatePublished - 2019

Fingerprint

Dive into the research topics of 'Probing transient non-native states in amyloid beta fiber elongation by NMR'. Together they form a unique fingerprint.

Cite this