Printed Silk Microelectrode Arrays for Electrophysiological Recording and Controlled Drug Delivery

Nouran Adly, Tetsuhiko F. Teshima, Hossein Hassani, George Al Boustani, Lennart J.K. Weiß, Gordon Cheng, Joe Alexander, Bernhard Wolfrum

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The use of soft and flexible bioelectronic interfaces can enhance the quality for recording cells’ electrical activity by ensuring a continuous and intimate contact with the smooth, curving surfaces found in the physiological environment. This work develops soft microelectrode arrays (MEAs) made of silk fibroin (SF) films for recording interfaces that can also serve as a drug delivery system. Inkjet printing is used as a tool to deposit the substrate, conductive electrode, and insulator, as well as a drug-delivery nanocomposite film. This approach is highly versatile, as shown in the fabrication of carbon microelectrodes, sandwiched between a silk substrate and a silk insulator. The technique permits the development of thin-film devices that can be employed for in vitro extracellular recordings of HL-1 cell action potentials. The tuning of SF by applying an electrical stimulus to produce a permeable layer that can be used in on-demand drug delivery systems is also demonstrated. The multifunctional MEA developed here can pave the way for in vitro drug screening by applying time-resolved and localized chemical stimuli.

Original languageEnglish
Article number2202869
JournalAdvanced Healthcare Materials
Volume12
Issue number17
DOIs
StatePublished - 6 Jul 2023

Keywords

  • additive manufacturing
  • cell recording
  • electrophysiology
  • inkjet
  • microelectrode arrays
  • microelectrodes
  • soft materials

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