Principles of pharmacology and toxicology also govern effects of chemicals on the endocrine system

Herman Autrup; Frank A. Barile; Bas J. Blaauboer; Gisela H. Degen; Wolfgang Dekant; Daniel Dietrich; Jose L. Domingo; Gio Batta Gori; Helmuth Greim; Jan G. Hengstler; Sam Kacew; Hans Marquardt; Olavi Pelkonen; Kai Savolainen; Nico P. Vermeulen

doi:10.1093/toxsci/kfv082

Principles of pharmacology and toxicology also govern effects of chemicals on the endocrine system

Herman Autrup, Frank A. Barile, Bas J. Blaauboer, Gisela H. Degen, Wolfgang Dekant, Daniel Dietrich, Jose L. Domingo, Gio Batta Gori, Helmuth Greim, Jan G. Hengstler, Sam Kacew, Hans Marquardt, Olavi Pelkonen, Kai Savolainen, Nico P. Vermeulen

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34 Scopus citations

Abstract

The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.

Original language	English
Pages (from-to)	11-15
Number of pages	5
Journal	Toxicological Sciences
Volume	146
Issue number	1
DOIs	https://doi.org/10.1093/toxsci/kfv082
State	Published - 1 Jul 2015

Keywords

Endocrine disruptors
Endocrine toxicology
Regulatory/policy
Risk assessment
Risk assessment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/toxsci/kfv082

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Autrup, H., Barile, F. A., Blaauboer, B. J., Degen, G. H., Dekant, W., Dietrich, D., Domingo, J. L., Gori, G. B., Greim, H., Hengstler, J. G., Kacew, S., Marquardt, H., Pelkonen, O., Savolainen, K., & Vermeulen, N. P. (2015). Principles of pharmacology and toxicology also govern effects of chemicals on the endocrine system. Toxicological Sciences, 146(1), 11-15. https://doi.org/10.1093/toxsci/kfv082

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abstract = "The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.",

keywords = "Endocrine disruptors, Endocrine toxicology, Regulatory/policy, Risk assessment, Risk assessment",

author = "Herman Autrup and Barile, {Frank A.} and Blaauboer, {Bas J.} and Degen, {Gisela H.} and Wolfgang Dekant and Daniel Dietrich and Domingo, {Jose L.} and Gori, {Gio Batta} and Helmuth Greim and Hengstler, {Jan G.} and Sam Kacew and Hans Marquardt and Olavi Pelkonen and Kai Savolainen and Vermeulen, {Nico P.}",

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Autrup, H, Barile, FA, Blaauboer, BJ, Degen, GH, Dekant, W, Dietrich, D, Domingo, JL, Gori, GB, Greim, H, Hengstler, JG, Kacew, S, Marquardt, H, Pelkonen, O, Savolainen, K & Vermeulen, NP 2015, 'Principles of pharmacology and toxicology also govern effects of chemicals on the endocrine system', Toxicological Sciences, vol. 146, no. 1, pp. 11-15. https://doi.org/10.1093/toxsci/kfv082

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AU - Autrup, Herman

AU - Barile, Frank A.

AU - Blaauboer, Bas J.

AU - Degen, Gisela H.

AU - Dekant, Wolfgang

AU - Dietrich, Daniel

AU - Domingo, Jose L.

AU - Gori, Gio Batta

AU - Greim, Helmuth

AU - Hengstler, Jan G.

AU - Kacew, Sam

AU - Marquardt, Hans

AU - Pelkonen, Olavi

AU - Savolainen, Kai

AU - Vermeulen, Nico P.

PY - 2015/7/1

Y1 - 2015/7/1

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AB - The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.

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KW - Endocrine toxicology

KW - Regulatory/policy

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SN - 1096-6080

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EP - 15

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Principles of pharmacology and toxicology also govern effects of chemicals on the endocrine system

Abstract

Keywords

UN SDGs

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