Principles and application of LIMS in mouse clinics

Holger Maier, Christine Schütt, Ralph Steinkamp, Anja Hurt, Elida Schneltzer, Philipp Gormanns, Christoph Lengger, Mark Griffiths, David Melvin, Neha Agrawal, Rafael Alcantara, Arthur Evans, David Gannon, Simon Holroyd, Christian Kipp, Navis Pretheeba Raj, David Richardson, Sophie LeBlanc, Laurent Vasseur, Hiroshi MasuyaKimio Kobayashi, Tomohiro Suzuki, Nobuhiko Tanaka, Shigeharu Wakana, Alison Walling, David Clary, Juan Gallegos, Helmut Fuchs, Martin Hrabě de Angelis, Valerie Gailus-Durner

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Large-scale systemic mouse phenotyping, as performed by mouse clinics for more than a decade, requires thousands of mice from a multitude of different mutant lines to be bred, individually tracked and subjected to phenotyping procedures according to a standardised schedule. All these efforts are typically organised in overlapping projects, running in parallel. In terms of logistics, data capture, data analysis, result visualisation and reporting, new challenges have emerged from such projects. These challenges could hardly be met with traditional methods such as pen & paper colony management, spreadsheet-based data management and manual data analysis. Hence, different Laboratory Information Management Systems (LIMS) have been developed in mouse clinics to facilitate or even enable mouse and data management in the described order of magnitude. This review shows that general principles of LIMS can be empirically deduced from LIMS used by different mouse clinics, although these have evolved differently. Supported by LIMS descriptions and lessons learned from seven mouse clinics, this review also shows that the unique LIMS environment in a particular facility strongly influences strategic LIMS decisions and LIMS development. As a major conclusion, this review states that there is no universal LIMS for the mouse research domain that fits all requirements. Still, empirically deduced general LIMS principles can serve as a master decision support template, which is provided as a hands-on tool for mouse research facilities looking for a LIMS.

Original languageEnglish
Pages (from-to)467-481
Number of pages15
JournalMammalian Genome
Volume26
Issue number9-10
DOIs
StatePublished - 1 Oct 2015
Externally publishedYes

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