Primary central nervous system lymphoma in a patient treated with natalizumab

Andreas Schweikert, Marcus Kremer, Florian Ringel, Thomas Liebig, Justus Duyster, Olaf Stüve, Bernhard Hemmer, Achim Berthele

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy. PCNSL is a disease of the elderly, with the majority of patients being diagnosed in the 7th to 8th decade of life. Immunodeficiency, iatrogenic immunosuppression, and some autoimmune diseases are known as predisposing conditions, and in these patients PCNSL peaks in the 4th decade. Because there is no increased prevalence of PCNSL in MS, and the patient was otherwise not immunocompromised, an association between natalizumab therapy and PCNSL cannot be ruled out.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
JournalAnnals of Neurology
Issue number3
StatePublished - 2009
Externally publishedYes


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