Prevention of toxic effects of cyclosporin on pancreatic b-cells of rats by Rioprostil, a new prostaglandin analogue

M. K. Muller, H. Degenhardt, G. Kloppel, H. Goebell, K. Bergmann, M. Lohr

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Cyclosporin 5, 10, and 20 mg/kg bw was given to rats once daily intragastrically and caused a dose dependent, significant decrease of glucose dependent insulin release from the arterially perfused isolated pancreas, without affecting animal behaviour, weight gain, microscopic appearances of the pancreas, or kidney function. Subcutaneous injection of a new synthetic prostaglandin analogue Rioprostil 7·5 μg/kg bw twice daily completely prevented the effect of cyclosporin 5 mglkg bw and protected significantly against the effects of cyclosporin 10 and 20 mg/kg bw.

Original languageEnglish
Pages (from-to)1524-1530
Number of pages7
JournalGut
Volume29
Issue number11
DOIs
StatePublished - 1988
Externally publishedYes

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