Prevention and treatment of relapse after stem cell transplantation by cellular therapies

Fred Falkenburg; Eliana Ruggiero; Chaira Bonini; David Porter; Jeff Miller; Floran Malard; Mohamad Mohty; Nicolaus Kröger; Hans Jochem Kolb

doi:10.1038/s41409-018-0227-0

Prevention and treatment of relapse after stem cell transplantation by cellular therapies

Fred Falkenburg, Eliana Ruggiero, Chaira Bonini, David Porter, Jeff Miller, Floran Malard, Mohamad Mohty, Nicolaus Kröger, Hans Jochem Kolb

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized.

Original language	English
Pages (from-to)	26-34
Number of pages	9
Journal	Bone Marrow Transplantation
Volume	54
Issue number	1
DOIs	https://doi.org/10.1038/s41409-018-0227-0
State	Published - 1 Jan 2019
Externally published	Yes

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title = "Prevention and treatment of relapse after stem cell transplantation by cellular therapies",

abstract = "Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized.",

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AU - Falkenburg, Fred

AU - Ruggiero, Eliana

AU - Bonini, Chaira

AU - Porter, David

AU - Miller, Jeff

AU - Malard, Floran

AU - Mohty, Mohamad

AU - Kröger, Nicolaus

AU - Kolb, Hans Jochem

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized.

AB - Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized.

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VL - 54

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JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

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Prevention and treatment of relapse after stem cell transplantation by cellular therapies

Abstract

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