Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy

K. Zier; B. Gansbacher; S. Salvadori

doi:10.1016/0167-5699(96)80567-6

Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy

K. Zier, B. Gansbacher, S. Salvadori

Mount Sinai School of Medicine

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

Recent evidence suggests that T cells from tumor-bearing patients exhibit abnormalities in signal transduction that render them unresponsive to appropriate activation signals. Here, Karen Zier, Bernd Gansbacher and Silvia Salvadori review evidence that gene therapy with interleukin 2 (IL-2)-secreting tumor-cell vaccines may prevent such signaling defects.

Original language	English
Pages (from-to)	39-45
Number of pages	7
Journal	Immunology Today
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/0167-5699(96)80567-6
State	Published - 1996
Externally published	Yes

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10.1016/0167-5699(96)80567-6

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title = "Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy",

abstract = "Recent evidence suggests that T cells from tumor-bearing patients exhibit abnormalities in signal transduction that render them unresponsive to appropriate activation signals. Here, Karen Zier, Bernd Gansbacher and Silvia Salvadori review evidence that gene therapy with interleukin 2 (IL-2)-secreting tumor-cell vaccines may prevent such signaling defects.",

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AU - Salvadori, S.

PY - 1996

Y1 - 1996

N2 - Recent evidence suggests that T cells from tumor-bearing patients exhibit abnormalities in signal transduction that render them unresponsive to appropriate activation signals. Here, Karen Zier, Bernd Gansbacher and Silvia Salvadori review evidence that gene therapy with interleukin 2 (IL-2)-secreting tumor-cell vaccines may prevent such signaling defects.

AB - Recent evidence suggests that T cells from tumor-bearing patients exhibit abnormalities in signal transduction that render them unresponsive to appropriate activation signals. Here, Karen Zier, Bernd Gansbacher and Silvia Salvadori review evidence that gene therapy with interleukin 2 (IL-2)-secreting tumor-cell vaccines may prevent such signaling defects.

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U2 - 10.1016/0167-5699(96)80567-6

DO - 10.1016/0167-5699(96)80567-6

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Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy

Abstract

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