Prevalence of antibodies to hepatitis C virus (HCV) in haemophiliacs

W. Schramm; M. Roggendorf; F. Rommel; R. Kammerer; H. Pohlmann; R. Raßhofer; L. Gürtler; F. Deinhardt

doi:10.1007/BF00321210

Prevalence of antibodies to hepatitis C virus (HCV) in haemophiliacs

W. Schramm, M. Roggendorf, F. Rommel, R. Kammerer, H. Pohlmann, R. Raßhofer, L. Gürtler, F. Deinhardt

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The prevalence of 1) hepatitis C virus (HCV), an agent likely to be responsible for parenter transmitted hepatitis non-A, non-B, 2) hepatitis B virus (HBV) and 3) human immunodeficiency virus (HIV) infection was studied in 211 patients with clotting disorders(78% of the patients had residual factor activities of ≤2%). Of these patients 71% were positive for HBV markers and 44% for HIV markers. Using a new ELISA technique, 80% were anti-HCV-positive. The prevalence of anti-HCV was greater in patients with more severe clotting disorders and was related to the total amount of replacement therapy received; the prevalence was less in older patients. Seroconversion after a single exposure to dry heat-treated factor concentrates was documented in 3 patients 3-4 months after exposure.

Original language	English
Pages (from-to)	390-392
Number of pages	3
Journal	Blut
Volume	59
Issue number	4
DOIs	https://doi.org/10.1007/BF00321210
State	Published - Oct 1989
Externally published	Yes

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title = "Prevalence of antibodies to hepatitis C virus (HCV) in haemophiliacs",

abstract = "The prevalence of 1) hepatitis C virus (HCV), an agent likely to be responsible for parenter transmitted hepatitis non-A, non-B, 2) hepatitis B virus (HBV) and 3) human immunodeficiency virus (HIV) infection was studied in 211 patients with clotting disorders(78% of the patients had residual factor activities of ≤2%). Of these patients 71% were positive for HBV markers and 44% for HIV markers. Using a new ELISA technique, 80% were anti-HCV-positive. The prevalence of anti-HCV was greater in patients with more severe clotting disorders and was related to the total amount of replacement therapy received; the prevalence was less in older patients. Seroconversion after a single exposure to dry heat-treated factor concentrates was documented in 3 patients 3-4 months after exposure.",

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T1 - Prevalence of antibodies to hepatitis C virus (HCV) in haemophiliacs

AU - Schramm, W.

AU - Roggendorf, M.

AU - Rommel, F.

AU - Kammerer, R.

AU - Pohlmann, H.

AU - Raßhofer, R.

AU - Gürtler, L.

AU - Deinhardt, F.

PY - 1989/10

Y1 - 1989/10

N2 - The prevalence of 1) hepatitis C virus (HCV), an agent likely to be responsible for parenter transmitted hepatitis non-A, non-B, 2) hepatitis B virus (HBV) and 3) human immunodeficiency virus (HIV) infection was studied in 211 patients with clotting disorders(78% of the patients had residual factor activities of ≤2%). Of these patients 71% were positive for HBV markers and 44% for HIV markers. Using a new ELISA technique, 80% were anti-HCV-positive. The prevalence of anti-HCV was greater in patients with more severe clotting disorders and was related to the total amount of replacement therapy received; the prevalence was less in older patients. Seroconversion after a single exposure to dry heat-treated factor concentrates was documented in 3 patients 3-4 months after exposure.

AB - The prevalence of 1) hepatitis C virus (HCV), an agent likely to be responsible for parenter transmitted hepatitis non-A, non-B, 2) hepatitis B virus (HBV) and 3) human immunodeficiency virus (HIV) infection was studied in 211 patients with clotting disorders(78% of the patients had residual factor activities of ≤2%). Of these patients 71% were positive for HBV markers and 44% for HIV markers. Using a new ELISA technique, 80% were anti-HCV-positive. The prevalence of anti-HCV was greater in patients with more severe clotting disorders and was related to the total amount of replacement therapy received; the prevalence was less in older patients. Seroconversion after a single exposure to dry heat-treated factor concentrates was documented in 3 patients 3-4 months after exposure.

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Prevalence of antibodies to hepatitis C virus (HCV) in haemophiliacs

Abstract

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