TY - JOUR
T1 - Prevalence of a First-Degree Relative With Colorectal Cancer and Uptake of Screening Among Persons 40 to 54 Years Old
AU - Weigl, Korbinian
AU - Tikk, Kaja
AU - Hoffmeister, Michael
AU - Hampe, Jochen
AU - Igel, Svitlana
AU - Kolligs, Frank
AU - Klug, Stefanie J.
AU - Mansmann, Ulrich
AU - Müller, Oliver
AU - Nagel, Jutta M.
AU - Pichler, Marcus
AU - Schwab, Matthias
AU - Schweigler, Dirk
AU - Stephan, Anna Magdalena
AU - De Toni, Enrico N.
AU - Brenner, Hermann
N1 - Publisher Copyright:
© 2020 AGA Institute
PY - 2020/10
Y1 - 2020/10
N2 - Background & Aims: People with a first-degree relative with colorectal cancer (CRC) are recommended to start CRC screening at age 40. However, there is limited information on how many people in different age groups have a known family history of CRC and how many of them have had a colonoscopy. Methods: We set up a multicenter, cross-sectional, population-based study in Germany to determine what proportions of persons in age groups from 40 to 54 years old have a known family history of CRC. We invited 160,000 persons to participate in an online survey from 2015 through 2016. We investigated what proportions of persons in each age group reported a family history of CRC and what proportions of persons underwent a colonoscopy examination using descriptive statistics and multiple logistic regression models. Results: Of 28,711 responders to the online questionnaire (8428 were age 40–44 years, 9879 were age 45–49 years, and 10,404 were age 50–54 years), 2705 stated that they had a first-degree relative with CRC (9.4%). The prevalence of a first-degree relative with CRC increased with age: 7.5%, 9.6%, and 10.9% for people 40 to 44 years old, 45 to 49 years old, and 50 to 54 years old, respectively. The prevalence of a first-degree relative who received a diagnosis of CRC at age 70 years or older increased steadily with each age group. Although a greater proportion of people with a family history of CRC had undergone a colonoscopy examination (54.5%) than people without a family history of CRC (25.7%; P <.0001), large proportions of people within this risk group were not in compliance with the guidelines (54.8%, 47.6%, and 38.6% for ages 40–44 y, 45–49 y, and 50–54 y, respectively). Conclusions: One in 10 persons in Germany age 40 to 54 years old has a first-degree relative with CRC. Guidelines recommend initiation of screening at ages 40 to 45 years for people with a family history, yet at this age many people do not have a family history of CRC yet, and almost half of persons 40 to 54 years old with a family history of CRC have not yet received a screening colonoscopy.
AB - Background & Aims: People with a first-degree relative with colorectal cancer (CRC) are recommended to start CRC screening at age 40. However, there is limited information on how many people in different age groups have a known family history of CRC and how many of them have had a colonoscopy. Methods: We set up a multicenter, cross-sectional, population-based study in Germany to determine what proportions of persons in age groups from 40 to 54 years old have a known family history of CRC. We invited 160,000 persons to participate in an online survey from 2015 through 2016. We investigated what proportions of persons in each age group reported a family history of CRC and what proportions of persons underwent a colonoscopy examination using descriptive statistics and multiple logistic regression models. Results: Of 28,711 responders to the online questionnaire (8428 were age 40–44 years, 9879 were age 45–49 years, and 10,404 were age 50–54 years), 2705 stated that they had a first-degree relative with CRC (9.4%). The prevalence of a first-degree relative with CRC increased with age: 7.5%, 9.6%, and 10.9% for people 40 to 44 years old, 45 to 49 years old, and 50 to 54 years old, respectively. The prevalence of a first-degree relative who received a diagnosis of CRC at age 70 years or older increased steadily with each age group. Although a greater proportion of people with a family history of CRC had undergone a colonoscopy examination (54.5%) than people without a family history of CRC (25.7%; P <.0001), large proportions of people within this risk group were not in compliance with the guidelines (54.8%, 47.6%, and 38.6% for ages 40–44 y, 45–49 y, and 50–54 y, respectively). Conclusions: One in 10 persons in Germany age 40 to 54 years old has a first-degree relative with CRC. Guidelines recommend initiation of screening at ages 40 to 45 years for people with a family history, yet at this age many people do not have a family history of CRC yet, and almost half of persons 40 to 54 years old with a family history of CRC have not yet received a screening colonoscopy.
KW - Colorectal Neoplasms
KW - Family History
KW - Screening
UR - http://www.scopus.com/inward/record.url?scp=85089447790&partnerID=8YFLogxK
U2 - 10.1016/j.cgh.2019.11.044
DO - 10.1016/j.cgh.2019.11.044
M3 - Article
C2 - 31809916
AN - SCOPUS:85089447790
SN - 1542-3565
VL - 18
SP - 2535-2543.e3
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 11
ER -