TY - JOUR
T1 - Prevalence and clinical role of GBV-C infection after cardiac surgery in childhood
T2 - A study on 414 patients
AU - Vogt, Manfred
AU - Klostermann, Barbara
AU - Braun, Siegmund
AU - Busch, Raymonde
AU - Hess, John
AU - Frösner, Gert
AU - Lang, Thomas
PY - 2006/7
Y1 - 2006/7
N2 - Objectives: GB-virus C (GBV-C) and hepatitis C virus (HCV) share similar modes of transmission. We, therefore, examined the prevalence and clinical role of GBV-C and HCV in patients after cardiac surgery in childhood. Methods: We analysed blood samples of 414 patients and compared them to 487 controls. Evidence of liver disease and risk factors for infection was analysed. Results: Overall prevalence of GBV-C infection was 22.5% in the patients, compared to 6.2% in the controls (HCV infection 11.3 vs. 0.7%). GBV-C RNA was detected in 8.2% of the patients vs. 3.7% in the controls (HCV RNA in 6 and 0%, respectively). Eleven patients had detectable RNA of GBV-C and HCV. 63.4% of patients infected with GBV-C and 46.8% of patients infected with HCV cleared the virus from circulation. GBV-C infection was not associated with hepatitis. Liver disease was not more frequent in patients co-infected with HCV and GBV-C. Conclusions: before 1991 have a substantial risk for HCV and GBV-C infection. However, GBV-C infection seems not to be associated with a liver disease. Co-infection with GBV-C and HCV has no influence on long-term clinical outcome or viral clearance of HCV infection.
AB - Objectives: GB-virus C (GBV-C) and hepatitis C virus (HCV) share similar modes of transmission. We, therefore, examined the prevalence and clinical role of GBV-C and HCV in patients after cardiac surgery in childhood. Methods: We analysed blood samples of 414 patients and compared them to 487 controls. Evidence of liver disease and risk factors for infection was analysed. Results: Overall prevalence of GBV-C infection was 22.5% in the patients, compared to 6.2% in the controls (HCV infection 11.3 vs. 0.7%). GBV-C RNA was detected in 8.2% of the patients vs. 3.7% in the controls (HCV RNA in 6 and 0%, respectively). Eleven patients had detectable RNA of GBV-C and HCV. 63.4% of patients infected with GBV-C and 46.8% of patients infected with HCV cleared the virus from circulation. GBV-C infection was not associated with hepatitis. Liver disease was not more frequent in patients co-infected with HCV and GBV-C. Conclusions: before 1991 have a substantial risk for HCV and GBV-C infection. However, GBV-C infection seems not to be associated with a liver disease. Co-infection with GBV-C and HCV has no influence on long-term clinical outcome or viral clearance of HCV infection.
KW - Children
KW - Clinical manifestation
KW - Coinfection
KW - GBV-C
KW - HCV
KW - Transfusion
UR - http://www.scopus.com/inward/record.url?scp=33745506789&partnerID=8YFLogxK
U2 - 10.1016/j.jinf.2005.08.030
DO - 10.1016/j.jinf.2005.08.030
M3 - Article
C2 - 16253334
AN - SCOPUS:33745506789
SN - 0163-4453
VL - 53
SP - 43
EP - 48
JO - Journal of Infection
JF - Journal of Infection
IS - 1
ER -
