Preservation time dependent morphological changes in cold stored human donor pancreas

Peter In t. Veld, Horst Nizze, Günter Klöppel

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Pancreatic transplantation is being used to treat insulin-dependent diabetes. An intact structure of the graft is a prerequisite for preserved function and we therefore monitored the light microscopic and ultrastructural changes in 30 human donor pancreases stored in the cold in University of Wisconsin preservation solution. Twenty-three pancreases were stored for less than 24 h and 7 for more than 30 h. All glands stored longer than 30 h displayed cytoplasmic vacuolisation in a variable proportion of acinar cells. In addition, the glands stored over 40 h showed focal acinar necrosis. Endocrine tissue was only slightly affected, while duct cells showed no changes. It is concluded that cold preserved pancreases stored for less than 24 h are best for transplantation purposes and that acinar cells are more sensitive to ischaemic damage than endocrine and duct cells.

Original languageEnglish
Pages (from-to)477-481
Number of pages5
JournalVirchows Archiv A Pathological Anatomy and Histopathology
Issue number6
StatePublished - Nov 1993
Externally publishedYes


  • Acinar cells
  • Cold preservation
  • Donor pancreas
  • Islets
  • Transplantation


Dive into the research topics of 'Preservation time dependent morphological changes in cold stored human donor pancreas'. Together they form a unique fingerprint.

Cite this