Prenylfuranocoumarin-HMGA-flavonol glucoside conjugates and other constituents of the fruit peels of Citrus hystrix and their anticholinesterase activity

Chonticha Seeka; Pakawadee Sutthivaiyakit; Juthamanee Youkwan; Norbert Hertkorn; Mourad Harir; Philippe Schmitt-Kopplin; Somyote Sutthivaiyakit

doi:10.1016/j.phytochem.2016.03.009

Prenylfuranocoumarin-HMGA-flavonol glucoside conjugates and other constituents of the fruit peels of Citrus hystrix and their anticholinesterase activity

Chonticha Seeka, Pakawadee Sutthivaiyakit, Juthamanee Youkwan, Norbert Hertkorn, Mourad Harir, Philippe Schmitt-Kopplin, Somyote Sutthivaiyakit

Chair of Analytical Food Chemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Sixteen compounds including dihydroxy prenylfuranocoumarins/3-hydroxy-3-methylglutaric acid conjugates and dihydroxy prenylfuranocoumarins/3-hydroxy-3-methylglutaric acid/1-O-flavonyl-β-d-glucopyranoside conjugates, together with other dihydroxyprenylfuranocoumarins conjugates, were isolated from the ethyl acetate extract of the fruit peels of Citrus hystrix. Some of the isolates were evaluated for their cholinesterase inhibitory activity, but only one compound possessing a 3-O-β-d-glucopyranosyl-3,5,7,4′-tetrahydroxy-6,8,3′-trimethoxyflavonol nucleus in the prenylfuranocoumarin-HMGA conjugate showed strong activity.

Original language	English
Pages (from-to)	38-49
Number of pages	12
Journal	Phytochemistry
Volume	127
DOIs	https://doi.org/10.1016/j.phytochem.2016.03.009
State	Published - 1 Jul 2016

Keywords

Anticholinesterase activity
Citrus hystrix
Flavonol glucosides
Hydroxymethyl glutaric acid (HMGA) ester
Prenylfuranocoumarins
Rutaceae

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10.1016/j.phytochem.2016.03.009

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title = "Prenylfuranocoumarin-HMGA-flavonol glucoside conjugates and other constituents of the fruit peels of Citrus hystrix and their anticholinesterase activity",

abstract = "Sixteen compounds including dihydroxy prenylfuranocoumarins/3-hydroxy-3-methylglutaric acid conjugates and dihydroxy prenylfuranocoumarins/3-hydroxy-3-methylglutaric acid/1-O-flavonyl-β-d-glucopyranoside conjugates, together with other dihydroxyprenylfuranocoumarins conjugates, were isolated from the ethyl acetate extract of the fruit peels of Citrus hystrix. Some of the isolates were evaluated for their cholinesterase inhibitory activity, but only one compound possessing a 3-O-β-d-glucopyranosyl-3,5,7,4′-tetrahydroxy-6,8,3′-trimethoxyflavonol nucleus in the prenylfuranocoumarin-HMGA conjugate showed strong activity.",

keywords = "Anticholinesterase activity, Citrus hystrix, Flavonol glucosides, Hydroxymethyl glutaric acid (HMGA) ester, Prenylfuranocoumarins, Rutaceae",

author = "Chonticha Seeka and Pakawadee Sutthivaiyakit and Juthamanee Youkwan and Norbert Hertkorn and Mourad Harir and Philippe Schmitt-Kopplin and Somyote Sutthivaiyakit",

note = "Publisher Copyright: {\textcopyright} 2016 Published by Elsevier Ltd.",

year = "2016",

month = jul,

day = "1",

doi = "10.1016/j.phytochem.2016.03.009",

language = "English",

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T1 - Prenylfuranocoumarin-HMGA-flavonol glucoside conjugates and other constituents of the fruit peels of Citrus hystrix and their anticholinesterase activity

AU - Seeka, Chonticha

AU - Sutthivaiyakit, Pakawadee

AU - Youkwan, Juthamanee

AU - Hertkorn, Norbert

AU - Harir, Mourad

AU - Schmitt-Kopplin, Philippe

AU - Sutthivaiyakit, Somyote

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Sixteen compounds including dihydroxy prenylfuranocoumarins/3-hydroxy-3-methylglutaric acid conjugates and dihydroxy prenylfuranocoumarins/3-hydroxy-3-methylglutaric acid/1-O-flavonyl-β-d-glucopyranoside conjugates, together with other dihydroxyprenylfuranocoumarins conjugates, were isolated from the ethyl acetate extract of the fruit peels of Citrus hystrix. Some of the isolates were evaluated for their cholinesterase inhibitory activity, but only one compound possessing a 3-O-β-d-glucopyranosyl-3,5,7,4′-tetrahydroxy-6,8,3′-trimethoxyflavonol nucleus in the prenylfuranocoumarin-HMGA conjugate showed strong activity.

AB - Sixteen compounds including dihydroxy prenylfuranocoumarins/3-hydroxy-3-methylglutaric acid conjugates and dihydroxy prenylfuranocoumarins/3-hydroxy-3-methylglutaric acid/1-O-flavonyl-β-d-glucopyranoside conjugates, together with other dihydroxyprenylfuranocoumarins conjugates, were isolated from the ethyl acetate extract of the fruit peels of Citrus hystrix. Some of the isolates were evaluated for their cholinesterase inhibitory activity, but only one compound possessing a 3-O-β-d-glucopyranosyl-3,5,7,4′-tetrahydroxy-6,8,3′-trimethoxyflavonol nucleus in the prenylfuranocoumarin-HMGA conjugate showed strong activity.

KW - Anticholinesterase activity

KW - Citrus hystrix

KW - Flavonol glucosides

KW - Hydroxymethyl glutaric acid (HMGA) ester

KW - Prenylfuranocoumarins

KW - Rutaceae

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U2 - 10.1016/j.phytochem.2016.03.009

DO - 10.1016/j.phytochem.2016.03.009

M3 - Article

C2 - 26995149

AN - SCOPUS:84961942694

SN - 0031-9422

VL - 127

SP - 38

EP - 49

JO - Phytochemistry

JF - Phytochemistry

ER -

Prenylfuranocoumarin-HMGA-flavonol glucoside conjugates and other constituents of the fruit peels of Citrus hystrix and their anticholinesterase activity

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