TY - JOUR
T1 - Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children
T2 - First evidence of polar overdominance in humans
AU - Wermter, Anne Kathrin
AU - Scherag, André
AU - Meyre, David
AU - Reichwald, Kathrin
AU - Durand, Emmanuelle
AU - Nguyen, Thuy Trang
AU - Koberwitz, Kerstin
AU - Lichtner, Peter
AU - Meitinger, Thomas
AU - Schäfer, Helmut
AU - Hinney, Anke
AU - Froguel, Philippe
AU - Hebebrand, Johannes
AU - Brönner, Günter
N1 - Funding Information:
We thank Gudrun Höhn, Gerti Gerber and Jitka Andrä for expert technical assistance. This work was supported by grants from the European Union (FP6 LSHMCT-2003-503041), the Bundesministerium für Bildung und Forschung (NGFN2 01GS0482, 01GS0483, 01GR0460) and the Deutsche Forschungsgemeinschaft (HE 1446/4-1).
PY - 2008
Y1 - 2008
N2 - DLK1 is part of the Notch signalling pathway that controls various developmental processes. A functional role for DLK1 in adipogenesis is suggested by several animal models. Interestingly, the DLK1 gene is imprinted in eutherian mammals. To study whether variations in DLK1 affect body weight in humans, we analysed 32 polymorphisms in a 109kb genomic region encompassing DLK1 on human chromosome 14. In a study sample of 1025 French and German trio families comprised of both parents and extremely obese offspring we found a single nucleotide polymorphism (rs1802710) associated with child and adolescent obesity. Analysis of the allelic transmission pattern indicated the existence of polar overdominance, an unusual mode of non-mendelian inheritance in humans previously known from the callipyge mutation in sheep.
AB - DLK1 is part of the Notch signalling pathway that controls various developmental processes. A functional role for DLK1 in adipogenesis is suggested by several animal models. Interestingly, the DLK1 gene is imprinted in eutherian mammals. To study whether variations in DLK1 affect body weight in humans, we analysed 32 polymorphisms in a 109kb genomic region encompassing DLK1 on human chromosome 14. In a study sample of 1025 French and German trio families comprised of both parents and extremely obese offspring we found a single nucleotide polymorphism (rs1802710) associated with child and adolescent obesity. Analysis of the allelic transmission pattern indicated the existence of polar overdominance, an unusual mode of non-mendelian inheritance in humans previously known from the callipyge mutation in sheep.
UR - http://www.scopus.com/inward/record.url?scp=50149083052&partnerID=8YFLogxK
U2 - 10.1038/ejhg.2008.64
DO - 10.1038/ejhg.2008.64
M3 - Article
C2 - 18398438
AN - SCOPUS:50149083052
SN - 1018-4813
VL - 16
SP - 1126
EP - 1134
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
IS - 9
ER -