TY - JOUR
T1 - PredictProtein - An open resource for online prediction of protein structural and functional features
AU - Yachdav, Guy
AU - Kloppmann, Edda
AU - Kajan, Laszlo
AU - Hecht, Maximilian
AU - Goldberg, Tatyana
AU - Hamp, Tobias
AU - Hönigschmid, Peter
AU - Schafferhans, Andrea
AU - Roos, Manfred
AU - Bernhofer, Michael
AU - Richter, Lothar
AU - Ashkenazy, Haim
AU - Punta, Marco
AU - Schlessinger, Avner
AU - Bromberg, Yana
AU - Schneider, Reinhard
AU - Vriend, Gerrit
AU - Sander, Chris
AU - Ben-Tal, Nir
AU - Rost, Burkhard
PY - 2014/7/1
Y1 - 2014/7/1
N2 - PredictProtein is a meta-service for sequence analysis that has been predicting structural and functional features of proteins since 1992. Queried with a protein sequence it returns: multiple sequence alignments, predicted aspects of structure (secondary structure, solvent accessibility, transmembrane helices (TMSEG) and strands, coiled-coil regions, disulfide bonds and disordered regions) and function. The service incorporates analysis methods for the identification of functional regions (ConSurf), homology-based inference of Gene Ontology terms (metastudent), comprehensive subcellular localization prediction (LocTree3), protein-protein binding sites (ISIS2), protein-polynucleotide binding sites (SomeNA) and predictions of the effect of point mutations (non-synonymous SNPs) on protein function (SNAP2). Our goal has always been to develop a system optimized to meet the demands of experimentalists not highly experienced in bioinformatics. To this end, the PredictProtein results are presented as both text and a series of intuitive, interactive and visually appealing figures. The web server and sources are available at http://ppopen.rostlab.org.
AB - PredictProtein is a meta-service for sequence analysis that has been predicting structural and functional features of proteins since 1992. Queried with a protein sequence it returns: multiple sequence alignments, predicted aspects of structure (secondary structure, solvent accessibility, transmembrane helices (TMSEG) and strands, coiled-coil regions, disulfide bonds and disordered regions) and function. The service incorporates analysis methods for the identification of functional regions (ConSurf), homology-based inference of Gene Ontology terms (metastudent), comprehensive subcellular localization prediction (LocTree3), protein-protein binding sites (ISIS2), protein-polynucleotide binding sites (SomeNA) and predictions of the effect of point mutations (non-synonymous SNPs) on protein function (SNAP2). Our goal has always been to develop a system optimized to meet the demands of experimentalists not highly experienced in bioinformatics. To this end, the PredictProtein results are presented as both text and a series of intuitive, interactive and visually appealing figures. The web server and sources are available at http://ppopen.rostlab.org.
UR - https://www.scopus.com/pages/publications/84904418029
U2 - 10.1093/nar/gku366
DO - 10.1093/nar/gku366
M3 - Article
C2 - 24799431
AN - SCOPUS:84904418029
SN - 0305-1048
VL - 42
SP - W337-W343
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - W1
ER -