Prediction of protein-protein complex structures by docking

Most cellular functions are mediated by the interaction of proteins to form dimeric or multimeric complexes as functional elements. Protein-protein complex structure can be predicted by computational protein-protein docking methods. A variety of docking methodologies are available and can be accessed as Web servers or stand-alone applications. The chapter is intended to give an overview on available approaches, on the refinement and scoring of predicted structures and discusses recent progress and future challenges of the protein-protein docking field.