Predicting type I diabetes

Anette G. Ziegler, Raymonde Dumont Herskowitz, Richard A. Jackson, J. Stuart Soeldner, George S. Eisenbarth

Research output: Contribution to journalReview articlepeer-review

94 Scopus citations


Currently, there are three markers that are being studied with the potential to give a high positive predictive value for the development of type I diabetes (insulin-dependent diabetes caused by autoimmune β-cell destruction) and that can be utilized to predict the disease in susceptible relatives: 1) high-titer cytoplasmic islet cell antibodies, 2) insulin autoantibodies detected with fluid-phase radiobinding assays, and 3) first-phase insulin release after intravenous glucose <1st percentile. With the combination of these assays, it seems to be possible to identify first-degree relatives with a high probability of developing type I diabetes within a limited time span (i.e., <10 yr). The ability to predict type I diabetes with selected assays will allow trials for prevention of diabetes and trials to assess whether prediction will decrease morbidity and mortality at onset of diabetes.

Original languageEnglish
Pages (from-to)762-775
Number of pages14
JournalDiabetes Care
Issue number7
StatePublished - Jul 1990


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