Predicted clinical factors associated with the intensive care unit length of stay after total cavopulmonary connection

Masamichi Ono, Melchior Burri, Gunter Balling, Elisabeth Beran, Julie Cleuziou, Jelena Pabst von Ohain, Martina Strbad, Alfred Hager, Jürgen Hörer, Rüdiger Lange

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Objectives: A longer length of stay (LOS) in the intensive care unit (ICU) after the total cavopulmonary connection (TCPC) is thought to be a predictive sign of late Fontan failure. This study was performed to determine the clinical risk factors for ICU LOS. Methods: In total, 483 patients who underwent a TCPC between May 1994 and December 2016 were included the study. Patients’ main diagnosis, morphologic characteristics, palliative procedures, hemodynamic parameters, and perioperative variables, were analyzed to identify risk factors influencing ICU stay based on Cox regression. Causes of longer ICU LOS and the impact of ICU LOS on late outcomes were evaluated. Results: Age at TCPC, type of TCPC, and fenestration at TCPC did not affect the ICU LOS. With multivariable model, hypoplastic left heart syndrome (P =.001) and anomalous systemic venous drainage (P <.001) were identified as independent morphologic risk factors for prolonged ICU LOS. Of hemodynamic variables, preoperative high transpulmonary gradient (P =.037), and low aortic oxygen saturation (P =.031) were risks for longer ICU LOS. Of postoperative variables, pleural effusion (P <.001), chylothorax (P =.001), ascites (P <.001), and infection (P =.028) were risks for longer ICU LOS. The ICU LOS was found to be significantly associated with late mortality (P <.001) and late cardiac reoperation (P =.007). Conclusions: Patients with hypoplastic left heart syndrome and anomalous systemic venous drainage had longer ICU LOS. Extended cyanosis and elevated pulmonary artery pressure affect the ICU LOS. Special care should be provided during the initial postoperative phase in patients with such risk factors.

Original languageEnglish
Pages (from-to)2005-2013.e3
JournalJournal of Thoracic and Cardiovascular Surgery
Volume157
Issue number5
DOIs
StatePublished - May 2019

Keywords

  • anomalous systemic venous drainage
  • hypoplastic left heart syndrome
  • intensive care unit
  • pleural effusion
  • total cavopulmonary connection

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