TY - GEN
T1 - Preclinical x-ray dark-field radiography for pulmonary emphysema evaluation
AU - Yaroshenko, A.
AU - Meinel, F. G.
AU - Bech, M.
AU - Tapfer, A.
AU - Velroyen, A.
AU - Schleede, S.
AU - Muller, M.
AU - Auweter, S.
AU - Bohla, A.
AU - Yildirim, A. O.
AU - Nikolaou, K.
AU - Bamberg, F.
AU - Eickelberg, O.
AU - Reiser, M.
AU - Pfeiffer, F.
PY - 2013
Y1 - 2013
N2 - Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and dark-field signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the results, based on a combination of transmission and dark-field signals, revealed a distinct difference between emphysematous and control samples. Subsequently, the distribution of emphysema was mapped out per-pixel for the lungs and showed good agreement with histological findings.
AB - Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and dark-field signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the results, based on a combination of transmission and dark-field signals, revealed a distinct difference between emphysematous and control samples. Subsequently, the distribution of emphysema was mapped out per-pixel for the lungs and showed good agreement with histological findings.
KW - dark-field
KW - emphysema
KW - grating interferometer
KW - phase-contrast
KW - x-ray
UR - http://www.scopus.com/inward/record.url?scp=84881620384&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2013.6556489
DO - 10.1109/ISBI.2013.6556489
M3 - Conference contribution
AN - SCOPUS:84881620384
SN - 9781467364546
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 370
EP - 373
BT - ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging
T2 - 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
Y2 - 7 April 2013 through 11 April 2013
ER -