Precancerous lesions of the biliary tree

Günter Klöppel, Volkan Adsay, Björn Konukiewitz, Jörg Kleeff, Anna Melissa Schlitter, Irene Esposito

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


The neoplasms of the biliary tree include the carcinomas of the intra- and extrahepatic bile ducts, the gallbladder and the ampulla. Two types of precancerous lesions precede these adenocarcinomas: the flat and non-tumour forming type that is called biliary intraepithelial neoplasia, and the papillary and tumour-forming type that has been named intraductal papillary neoplasm of the bile duct. Rarely also biliary mucinous cystic neoplasm can give rise to invasive biliary adenocarcinomas. This review discusses the pathological, molecular, epidemiological, clinical and prognostic features of the precancerous biliary lesions, separated according to their origin in the bile ducts, the ampulla and the gall bladder.

Original languageEnglish
Pages (from-to)285-297
Number of pages13
JournalBailliere's Best Practice and Research in Clinical Gastroenterology
Issue number2
StatePublished - Apr 2013


  • Bile duct neoplasms
  • Biliary intraepithelial neoplasia
  • Intraductal papillary neoplasm
  • Invasive bile duct carcinoma
  • Precancerous conditions


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