TY - JOUR
T1 - Prdm6 is essential for cardiovascular development In Vivo
AU - Gewies, Andreas
AU - Castineiras-Vilarino, Mercedes
AU - Ferch, Uta
AU - Jährling, Nina
AU - Heinrich, Katja
AU - Hoeckendorf, Ulrike
AU - Przemeck, Gerhard K.H.
AU - Munding, Matthias
AU - Groß, Olaf
AU - Schroeder, Timm
AU - Horsch, Marion
AU - Karran, E. Loraine
AU - Majid, Aneela
AU - Antonowicz, Stefan
AU - Beckers, Johannes
AU - Hrabé De Angelis, Martin
AU - Dodt, Hans Ulrich
AU - Peschel, Christian
AU - Förster, Irmgard
AU - Dyer, Martin J.S.
AU - Ruland, Jürgen
PY - 2013/11/21
Y1 - 2013/11/21
N2 - Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated from Prdm6-deficient embryonic stem cells and vascular smooth muscle cells were present and proliferated normally in Prdm6-deficient embryos. Conditional deletion of Prdm6 in the smooth muscle cell lineage using a SM22-Cre driver line resulted in perinatal lethality due to hemorrhage in the lungs. We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development.
AB - Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated from Prdm6-deficient embryonic stem cells and vascular smooth muscle cells were present and proliferated normally in Prdm6-deficient embryos. Conditional deletion of Prdm6 in the smooth muscle cell lineage using a SM22-Cre driver line resulted in perinatal lethality due to hemorrhage in the lungs. We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development.
UR - https://www.scopus.com/pages/publications/84896695806
U2 - 10.1371/journal.pone.0081833
DO - 10.1371/journal.pone.0081833
M3 - Article
C2 - 24278461
AN - SCOPUS:84896695806
SN - 1932-6203
VL - 8
JO - PLoS ONE
JF - PLoS ONE
IS - 11
M1 - e81833
ER -