Practical: In situ -generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters

Lin Wang, Helfried Neumann, Anke Spannenberg, Matthias Beller

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

An effective method for alkoxycarbonylation of (hetero)aryl bromides is developed in the presence of in situ-generated phosphinite ligands tBu2POR (R = nBu, nPr, Et or Me). For this purpose commercially available tBu2PCl was used as the pre-ligand in the presence of different alcohols. For the first time cross coupling reactions with two alcohols-one generating the ligand, the other used as substrate-were developed. Through this method, ligand optimization can be performed in a more efficient manner and the desired products could be obtained with good yields and selectivity.

Original languageEnglish
Pages (from-to)7469-7472
Number of pages4
JournalChemical Communications
Volume53
Issue number54
DOIs
StatePublished - 2017
Externally publishedYes

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