TY - JOUR
T1 - Postmortale molekulargenetische Untersuchungen (molekulare Autopsie) bei kardiovaskulären und bei ungeklärten Todesfällen
T2 - Konsensuspapier der Deutschen Gesellschaft für Kardiologie (DGK), Deutschen Gesellschaft für Pädiatrische Kardiologie (DGPK), Deutschen Gesellschaft für Humangenetik (GfH), Deutschen Gesellschaft für Pathologie (DGP), Deutschen Gesellschaft für Rechtsmedizin (DGRM)
AU - Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e. V. (DGK)
AU - Deutsche Gesellschaft für Pädiatrische Kardiologie und Angeborene Herzfehler e. V. (DGPK)
AU - Deutsche Gesellschaft für Humangenetik e. V. (GfH)
AU - Deutsche Gesellschaft für Rechtsmedizin e. V. (DGRM)
AU - Deutsche Gesellschaft für Pathologie e. V. (DGP)
AU - Schulze-Bahr, Eric
AU - Dettmeyer, Reinhard B.
AU - Klingel, Karin
AU - Kauferstein, Silke
AU - Wolf, Cordula
AU - Baba, Hideo A.
AU - Bohle, Rainer M.
AU - Gebauer, Roman
AU - Milting, Hendrik
AU - Schmidt, Uwe
AU - Meder, Benjamin
AU - Rieß, Olaf
AU - Paul, Thomas
AU - Bajanowski, Thomas
AU - Schunkert, Heribert
N1 - Publisher Copyright:
© 2020, Deutsche Gesellschaft für Kardiologie - Herz- und Kreislaufforschung e.V. Published by Springer Medizin Verlag GmbH, ein Teil von Springer Nature - all rights reserved.
PY - 2021/3
Y1 - 2021/3
N2 - Autopsies (dissections or cadaver dissections) from clinical or forensic indications in cases of unclear, premature (usually <40 years of age, in individual cases also later) or cardiovascular deaths serve, in addition to the definitive clarification of the cause, to identify or distinguish between genetic causes. These are particularly relevant in preventive terms for biologically related family members, especially after extensive autopsies without determination of the cause of death (mors sine materia). A molecular autopsy aims at a postmortem clarification of the cause of death by identifying or confirming a hereditary cardiovascular disease. In this consensus paper, expert recommendations on the current necessity, indications and performance of a molecular autopsy are formulated. In addition, if a genetic cardiovascular disease is suspected, a systematic clinical (and possibly genetic) examination of family members should be performed.
AB - Autopsies (dissections or cadaver dissections) from clinical or forensic indications in cases of unclear, premature (usually <40 years of age, in individual cases also later) or cardiovascular deaths serve, in addition to the definitive clarification of the cause, to identify or distinguish between genetic causes. These are particularly relevant in preventive terms for biologically related family members, especially after extensive autopsies without determination of the cause of death (mors sine materia). A molecular autopsy aims at a postmortem clarification of the cause of death by identifying or confirming a hereditary cardiovascular disease. In this consensus paper, expert recommendations on the current necessity, indications and performance of a molecular autopsy are formulated. In addition, if a genetic cardiovascular disease is suspected, a systematic clinical (and possibly genetic) examination of family members should be performed.
KW - Arrhythmia
KW - Cardiomyopathy
KW - Molecular autopsy
KW - Mutation
KW - Sudden cardiac death
UR - http://www.scopus.com/inward/record.url?scp=85101742929&partnerID=8YFLogxK
U2 - 10.1007/s12181-020-00438-5
DO - 10.1007/s12181-020-00438-5
M3 - Übersichtsartikel
AN - SCOPUS:85101742929
SN - 1864-9718
VL - 15
SP - 176
EP - 193
JO - Kardiologe
JF - Kardiologe
IS - 2
ER -
