Polymorphism of Cross-Linked Actin Networks in Giant Vesicles

Laurent Limozin, Erich Sackmann

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124 Scopus citations

Abstract

Actin networks cross-linked by natural linkers [Formula presented]-actinin and filamin are generated in giant vesicles by polymerization through ionophore-mediated influx of [Formula presented]. [Formula presented]-actinin induces the formation of randomly linked networks at 25°C which transform at [Formula presented] into spiderweblike gels or ringlike bundles depending on the vesicle size. Muscle filamin forms ringlike structures under all experimental conditions which can supercoil by subsequent [Formula presented] addition. The polymorphism is rationalized in terms of recent models of bivalent ion coupled semiflexible polyelectrolytes and by considering the topology of the linkers.

Original languageEnglish
JournalPhysical Review Letters
Volume89
Issue number16
DOIs
StatePublished - 2002

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