Platinum-catalyzed intramolecular cyclizations of alkynes: efficient synthesis of pyrroloazepinone derivatives

Marina Gruit, Dirk Michalik, Annegret Tillack, Matthias Beller

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Achieving closure: A platinum-catalyzed cycloisomerization reaction (see scheme; [Pd/Cu]=[PdCl2 (PPh3)2]/Cul, Ar=aryl, X=Br,I) is used for the efficient straightforward synthesis of biologically relevant pyrrolo- [3,2-c]azepin-4-one derivatives.

Original languageEnglish
Pages (from-to)7212-7216
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume48
Issue number39
DOIs
StatePublished - 14 Sep 2009
Externally publishedYes

Keywords

  • Alkynes
  • Cyclization
  • Gold
  • Platinum
  • Pyrroles

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