Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

Horst Penkert; Chris Lauber; Mathias J. Gerl; Christian Klose; Markus Damm; Dirk Fitzner; Andrea Flierl-Hecht; Tania Kümpfel; Martin Kerschensteiner; Reinhard Hohlfeld; Lisa A. Gerdes; Mikael Simons

doi:10.1002/acn3.51216

Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

Horst Penkert, Chris Lauber, Mathias J. Gerl, Christian Klose, Markus Damm, Dirk Fitzner, Andrea Flierl-Hecht, Tania Kümpfel, Martin Kerschensteiner, Reinhard Hohlfeld, Lisa A. Gerdes, Mikael Simons

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Blood biomarkers of multiple sclerosis (MS) can provide a better understanding of pathophysiology and enable disease monitoring. Here, we performed quantitative shotgun lipidomics on the plasma of a unique cohort of 73 monozygotic twins discordant for MS. We analyzed 243 lipid species, evaluated lipid features such as fatty acyl chain length and number of acyl chain double bonds, and detected phospholipids that were significantly altered in the plasma of co-twins with MS compared to their non-affected siblings. Strikingly, changes were most prominent in ether phosphatidylethanolamines and ether phosphatidylcholines, suggesting a role for altered lipid signaling in the disease.

Original language	English
Pages (from-to)	2461-2466
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	7
Issue number	12
DOIs	https://doi.org/10.1002/acn3.51216
State	Published - Dec 2020
Externally published	Yes

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title = "Plasma lipidomics of monozygotic twins discordant for multiple sclerosis",

abstract = "Blood biomarkers of multiple sclerosis (MS) can provide a better understanding of pathophysiology and enable disease monitoring. Here, we performed quantitative shotgun lipidomics on the plasma of a unique cohort of 73 monozygotic twins discordant for MS. We analyzed 243 lipid species, evaluated lipid features such as fatty acyl chain length and number of acyl chain double bonds, and detected phospholipids that were significantly altered in the plasma of co-twins with MS compared to their non-affected siblings. Strikingly, changes were most prominent in ether phosphatidylethanolamines and ether phosphatidylcholines, suggesting a role for altered lipid signaling in the disease.",

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year = "2020",

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doi = "10.1002/acn3.51216",

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T1 - Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

AU - Penkert, Horst

AU - Lauber, Chris

AU - Gerl, Mathias J.

AU - Klose, Christian

AU - Damm, Markus

AU - Fitzner, Dirk

AU - Flierl-Hecht, Andrea

AU - Kümpfel, Tania

AU - Kerschensteiner, Martin

AU - Hohlfeld, Reinhard

AU - Gerdes, Lisa A.

AU - Simons, Mikael

PY - 2020/12

Y1 - 2020/12

N2 - Blood biomarkers of multiple sclerosis (MS) can provide a better understanding of pathophysiology and enable disease monitoring. Here, we performed quantitative shotgun lipidomics on the plasma of a unique cohort of 73 monozygotic twins discordant for MS. We analyzed 243 lipid species, evaluated lipid features such as fatty acyl chain length and number of acyl chain double bonds, and detected phospholipids that were significantly altered in the plasma of co-twins with MS compared to their non-affected siblings. Strikingly, changes were most prominent in ether phosphatidylethanolamines and ether phosphatidylcholines, suggesting a role for altered lipid signaling in the disease.

AB - Blood biomarkers of multiple sclerosis (MS) can provide a better understanding of pathophysiology and enable disease monitoring. Here, we performed quantitative shotgun lipidomics on the plasma of a unique cohort of 73 monozygotic twins discordant for MS. We analyzed 243 lipid species, evaluated lipid features such as fatty acyl chain length and number of acyl chain double bonds, and detected phospholipids that were significantly altered in the plasma of co-twins with MS compared to their non-affected siblings. Strikingly, changes were most prominent in ether phosphatidylethanolamines and ether phosphatidylcholines, suggesting a role for altered lipid signaling in the disease.

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DO - 10.1002/acn3.51216

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C2 - 33159711

AN - SCOPUS:85096643938

SN - 2328-9503

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SP - 2461

EP - 2466

JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

IS - 12

ER -

Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

Abstract

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