Plasma levels of soluble AβPPβ as a biomarker for Alzheimer's disease with dementia

Panagiotis Alexopoulos; Nathalie Thierjung; Polychronis Economou; Lukas Werle; Felix Buhl; Simone Kagerbauer; Anastasios D. Papanastasiou; Timo Grimmer; Philippos Gourzis; Achim Berthele; Bernhard Hemmer; Hubert Kübler; Jan Martin; Antonios Politis; Robert Perneczky

doi:10.3233/JAD-181088

Plasma levels of soluble AβPPβ as a biomarker for Alzheimer's disease with dementia

Panagiotis Alexopoulos, Nathalie Thierjung, Polychronis Economou, Lukas Werle, Felix Buhl, Simone Kagerbauer, Anastasios D. Papanastasiou, Timo Grimmer, Philippos Gourzis, Achim Berthele, Bernhard Hemmer, Hubert Kübler, Jan Martin, Antonios Politis, Robert Perneczky

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Abstract

Cost- and time-effective markers of Alzheimer's disease (AD), reliable and feasible at the population level are urgently needed. Soluble amyloid-β protein precursor β (sAβPPβ) in plasma has attracted scientific attention as a potential AD biomarker candidate. Here we report that plasma sAβPPβ levels in patients with AD dementia and typical for AD cerebrospinal fluid (CSF) biomarker profiles (N=33) are significantly lower (p<0.01) than those of cognitively healthy elderly individuals without AD (N=39), while CSF sAβPPβ levels did not differ between the studied groups. This provides further evidence for the potential of sAβPPβ in plasma as an AD biomarker candidate.

Original language	English
Pages (from-to)	83-90
Number of pages	8
Journal	Journal of Alzheimer's Disease
Volume	69
Issue number	1
DOIs	https://doi.org/10.3233/JAD-181088
State	Published - 2019

Keywords

Biomarker candidate
NIA-AA research framework diagnostic criteria
soluble amyloid-β protein precursor β

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Alexopoulos, P., Thierjung, N., Economou, P., Werle, L., Buhl, F., Kagerbauer, S., Papanastasiou, A. D., Grimmer, T., Gourzis, P., Berthele, A., Hemmer, B., Kübler, H., Martin, J., Politis, A., & Perneczky, R. (2019). Plasma levels of soluble AβPPβ as a biomarker for Alzheimer's disease with dementia. Journal of Alzheimer's Disease, 69(1), 83-90. https://doi.org/10.3233/JAD-181088

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title = "Plasma levels of soluble AβPPβ as a biomarker for Alzheimer's disease with dementia",

abstract = "Cost- and time-effective markers of Alzheimer's disease (AD), reliable and feasible at the population level are urgently needed. Soluble amyloid-β protein precursor β (sAβPPβ) in plasma has attracted scientific attention as a potential AD biomarker candidate. Here we report that plasma sAβPPβ levels in patients with AD dementia and typical for AD cerebrospinal fluid (CSF) biomarker profiles (N=33) are significantly lower (p<0.01) than those of cognitively healthy elderly individuals without AD (N=39), while CSF sAβPPβ levels did not differ between the studied groups. This provides further evidence for the potential of sAβPPβ in plasma as an AD biomarker candidate.",

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author = "Panagiotis Alexopoulos and Nathalie Thierjung and Polychronis Economou and Lukas Werle and Felix Buhl and Simone Kagerbauer and Papanastasiou, {Anastasios D.} and Timo Grimmer and Philippos Gourzis and Achim Berthele and Bernhard Hemmer and Hubert K{\"u}bler and Jan Martin and Antonios Politis and Robert Perneczky",

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Alexopoulos, P, Thierjung, N, Economou, P, Werle, L, Buhl, F, Kagerbauer, S, Papanastasiou, AD, Grimmer, T, Gourzis, P, Berthele, A , Hemmer, B, Kübler, H, Martin, J, Politis, A & Perneczky, R 2019, 'Plasma levels of soluble AβPPβ as a biomarker for Alzheimer's disease with dementia', Journal of Alzheimer's Disease, vol. 69, no. 1, pp. 83-90. https://doi.org/10.3233/JAD-181088

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T1 - Plasma levels of soluble AβPPβ as a biomarker for Alzheimer's disease with dementia

AU - Alexopoulos, Panagiotis

AU - Thierjung, Nathalie

AU - Economou, Polychronis

AU - Werle, Lukas

AU - Buhl, Felix

AU - Kagerbauer, Simone

AU - Papanastasiou, Anastasios D.

AU - Grimmer, Timo

AU - Gourzis, Philippos

AU - Berthele, Achim

AU - Hemmer, Bernhard

AU - Kübler, Hubert

AU - Martin, Jan

AU - Politis, Antonios

AU - Perneczky, Robert

PY - 2019

Y1 - 2019

N2 - Cost- and time-effective markers of Alzheimer's disease (AD), reliable and feasible at the population level are urgently needed. Soluble amyloid-β protein precursor β (sAβPPβ) in plasma has attracted scientific attention as a potential AD biomarker candidate. Here we report that plasma sAβPPβ levels in patients with AD dementia and typical for AD cerebrospinal fluid (CSF) biomarker profiles (N=33) are significantly lower (p<0.01) than those of cognitively healthy elderly individuals without AD (N=39), while CSF sAβPPβ levels did not differ between the studied groups. This provides further evidence for the potential of sAβPPβ in plasma as an AD biomarker candidate.

AB - Cost- and time-effective markers of Alzheimer's disease (AD), reliable and feasible at the population level are urgently needed. Soluble amyloid-β protein precursor β (sAβPPβ) in plasma has attracted scientific attention as a potential AD biomarker candidate. Here we report that plasma sAβPPβ levels in patients with AD dementia and typical for AD cerebrospinal fluid (CSF) biomarker profiles (N=33) are significantly lower (p<0.01) than those of cognitively healthy elderly individuals without AD (N=39), while CSF sAβPPβ levels did not differ between the studied groups. This provides further evidence for the potential of sAβPPβ in plasma as an AD biomarker candidate.

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KW - NIA-AA research framework diagnostic criteria

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JF - Journal of Alzheimer's Disease

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Plasma levels of soluble AβPPβ as a biomarker for Alzheimer's disease with dementia

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Keywords

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