Plasma levels of IL-1, TNF alpha, IL-6, IL-8, G-CSF, and IL1-RA during febrile neutropenia: Results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia

H. Schönbohn, M. Schuler, K. Kolbe, C. Peschel, C. Huber, W. Bemb, W. E. Aulitzky

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40 Scopus citations

Abstract

Plasma levels of IL-1, IL-6, IL-8, IL1-RA, TNF alpha, and G-CSF were prospectively studied during 23 chemotherapy cycles of 20 patients suffering from acute myelogenous leukemia. Increased plasma levels of IL-6, IL-8, and G-CSF were observed in patients with febrile neutropenia and/or major infection. Plasma levels of IL-6, IL-1, TNF alpha and IL-1-RA measured 1 day before and 1 day after the onset of febrile episodes did not accurately predict the development of major infection. In contrast, IL-8 plasma levels were significantly higher in those patients who subsequently developed major infection. The question whether IL-8 plasma levels identify high risk or low risk patients with sufficient specificity and sensitivity has to be answered in large scale clinical trials.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalAnnals of Hematology
Volume71
Issue number4
DOIs
StatePublished - Oct 1995
Externally publishedYes

Keywords

  • Interleukin
  • Neutropenia
  • Plasma levels

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