Plasma complement and histamine changes in atopic dermatitis

JOHANNES RING; THOMAS SENTER; ROGER C. CORNELL; CARLOS M. ARROYAVE; ENG M. TAN

doi:10.1111/j.1365-2133.1979.tb05577.x

Plasma complement and histamine changes in atopic dermatitis

JOHANNES RING, THOMAS SENTER, ROGER C. CORNELL, CARLOS M. ARROYAVE, ENG M. TAN

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Abstract

Fifteen patients with atopic dermatitis were investigated to evaluate the total of complement and histamine. In five patients total serum complement haemolytic activity (CH50) was significantly decreased as was the haemolytic activity of complement components C2 (C2H50) and C3 (C3H50) By counter immunoelectrophoresis split products of C3 were detected. There was no evidence for alternative pathway activation or the presence of an activator of the alternative pathway. In three patients plasma histamine concetrations were elevated. The intensity of the complement and histamine changes observed seemed to be correlated to the severity of the disease.

Original language	English
Pages (from-to)	521-530
Number of pages	10
Journal	British Journal of Dermatology
Volume	100
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2133.1979.tb05577.x
State	Published - May 1979
Externally published	Yes

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AU - SENTER, THOMAS

AU - CORNELL, ROGER C.

AU - ARROYAVE, CARLOS M.

AU - TAN, ENG M.

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AB - Fifteen patients with atopic dermatitis were investigated to evaluate the total of complement and histamine. In five patients total serum complement haemolytic activity (CH50) was significantly decreased as was the haemolytic activity of complement components C2 (C2H50) and C3 (C3H50) By counter immunoelectrophoresis split products of C3 were detected. There was no evidence for alternative pathway activation or the presence of an activator of the alternative pathway. In three patients plasma histamine concetrations were elevated. The intensity of the complement and histamine changes observed seemed to be correlated to the severity of the disease.

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Plasma complement and histamine changes in atopic dermatitis

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