Plättchenaggregation und Prostaglandinumsatz beim Menschen unter definierter Linolsäurezufuhr mit Formeldiäten

Translated title of the contribution: Platelet aggregation and prostaglandin turnover in man during defined linoleic acid supply with formula diets

O. Adam, M. Dill-Wiessner, G. Wolfram, N. Zöllner

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A report is given on changes of platelet aggregation and prostaglandin turnover during a cross-over experiment with six female volunteers being given a linoleic acid supply with formula diets of 0 g or 50 g daily. Collagen- and ADP-induced platelet aggregation was determined with a Borne-type aggregometer. Prostaglandin turnover was measured by analyzing the excretion of a joint derivative of prostaglandin metabolites, tetranorprostanedioic acid, in urine. With a linoleic acid supply of 50 g daily we found an increase of tetranorprostanedioic acid in urine, while platelet aggregation decreased. When the experimental subjects came from a conventional diet (linoleic acid intake 20 g daily) these changes were seen later than after a linoleic acid free formula diet. A linoleic acid-deficient formula diet caused a fall in prostaglandin turnover within 24 h. ADP-induced platelet aggregation was unchanged after 1 week, while collagen-induced platelet aggregation was increased after 1 and 3 weeks of linoleic acid-deficient diet. These results clearly demonstrate the influence of nutrition on platelet aggregation.

Translated title of the contributionPlatelet aggregation and prostaglandin turnover in man during defined linoleic acid supply with formula diets
Original languageGerman
Pages (from-to)227-235
Number of pages9
JournalResearch in Experimental Medicine
Volume177
Issue number3
DOIs
StatePublished - Oct 1980
Externally publishedYes

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