TY - JOUR
T1 - Pilomatrix carcinoma with multiple visceral metastases
T2 - Report of a case
AU - Niedermeyer, Hans P.
AU - Peris, Ketty
AU - Höfler, Heinz
PY - 1996/4/1
Y1 - 1996/4/1
N2 - BACKGROUND. The malignant variant of pilomatrixoma is pilomatrix carcinoma, a low grade, malignant lesion with a tendency to recur. Only three cases with visceral metastases, occurring some years after primary diagnosis, have been reported. METHODS. A case of metastatic pilomatrix carcinoma of the neck in a patient, age 50 years, is presented. RESULTS. Histologic examination of the cutaneous lesion showed a dense infiltrate of basaloid cells, an abrupt transition to shadow cells, and central necrosis. Two months after primary diagnosis, pulmonary and brain metastases developed. Despite chemotherapy and irradiation, the patient died of widespread disease 18 months after the primary diagnosis. An autopsy confirmed the diagnosis of pilomatrix carcinoma with metastases to several organs including the heart, lung, brain, liver, pancreas, kidney, adrenal gland, gastric and colorectal submucosa, skin, and bone. CONCLUSIONS. Pilomatrix carcinoma is very rare and usually behaves like a low-grade, malignant lesion with a tendency to recur. This patient's tumor is unique because of its highly aggressive behavior and visceral metastases.
AB - BACKGROUND. The malignant variant of pilomatrixoma is pilomatrix carcinoma, a low grade, malignant lesion with a tendency to recur. Only three cases with visceral metastases, occurring some years after primary diagnosis, have been reported. METHODS. A case of metastatic pilomatrix carcinoma of the neck in a patient, age 50 years, is presented. RESULTS. Histologic examination of the cutaneous lesion showed a dense infiltrate of basaloid cells, an abrupt transition to shadow cells, and central necrosis. Two months after primary diagnosis, pulmonary and brain metastases developed. Despite chemotherapy and irradiation, the patient died of widespread disease 18 months after the primary diagnosis. An autopsy confirmed the diagnosis of pilomatrix carcinoma with metastases to several organs including the heart, lung, brain, liver, pancreas, kidney, adrenal gland, gastric and colorectal submucosa, skin, and bone. CONCLUSIONS. Pilomatrix carcinoma is very rare and usually behaves like a low-grade, malignant lesion with a tendency to recur. This patient's tumor is unique because of its highly aggressive behavior and visceral metastases.
KW - head
KW - multiple metastasis
KW - neck
KW - pillomatrixoma
KW - pilomatrix carcinoma
UR - http://www.scopus.com/inward/record.url?scp=0029879699&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0142(19960401)77:7<1311::AID-CNCR13>3.0.CO;2-4
DO - 10.1002/(SICI)1097-0142(19960401)77:7<1311::AID-CNCR13>3.0.CO;2-4
M3 - Article
C2 - 8608508
AN - SCOPUS:0029879699
SN - 0008-543X
VL - 77
SP - 1311
EP - 1314
JO - Cancer
JF - Cancer
IS - 7
ER -