Physical Synthesis of Flow-Based Microfluidic Biochips Considering Distributed Channel Storage

Zhisheng Chen, Xing Huang, Wenzhong Guo, Bing Li, Tsung Yi Ho, Ulf Schlichtmann

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

24 Scopus citations

Abstract

Flow-based microfluidic biochips (FBMBs) have attracted much attention over the past decade. On such a micrometer-scale platform, various biochemical applications, also called bioas-says, can be processed concurrently and automatically. To improve execution efficiency and reduce fabrication cost, a distributed channel-storage architecture (DCSA) can be implemented on this platform, where fluid samples can be cached temporarily in flow channels close to components. Although DCSA can improve the execution efficiency of FBMBs significantly, it requires a careful arrangement of fluid samples to enable the channels to fulfill the dual functions of transportation and caching. In this paper, we formulate the first flow-layer physical design problem considering DCSA, and propose a top-down synthesis algorithm to generate efficient solutions considering execution efficiency, washing, and resource usage simultaneously. Experimental results demonstrate that the proposed algorithm leads to a shorter execution time, less flow-channel length, and a higher efficiency of on-chip resource utilization for biochemical applications compared with a direct approach to incorporate distributed storage into existing frameworks.

Original languageEnglish
Title of host publicationProceedings of the 2019 Design, Automation and Test in Europe Conference and Exhibition, DATE 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1525-1530
Number of pages6
ISBN (Electronic)9783981926323
DOIs
StatePublished - 14 May 2019
Event22nd Design, Automation and Test in Europe Conference and Exhibition, DATE 2019 - Florence, Italy
Duration: 25 Mar 201929 Mar 2019

Publication series

NameProceedings of the 2019 Design, Automation and Test in Europe Conference and Exhibition, DATE 2019

Conference

Conference22nd Design, Automation and Test in Europe Conference and Exhibition, DATE 2019
Country/TerritoryItaly
CityFlorence
Period25/03/1929/03/19

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